Purpose Of Review: The current review highlights recent advances in treatment of chronic hepatitis C virus infection using new classes of agents, direct-acting antivirals (DAAs), with a focus on the evidence for their use in the setting of chronic kidney disease (CKD) stages 4-5, hemodialysis, and kidney transplantation.
Recent Findings: DAA agents target-specific proteins involved in the hepatitis C virus life cycle and interrupt viral replication. Sustained virologic response, a marker of viral eradication, occurs in more than 90% of patients treated with DAA agents in the general population. Emerging data demonstrate similar sustained virologic response rates for specific DAA-based regimens in patients with CKD stages 4-5, hemodialysis patients, and kidney-transplant recipients.
Summary: High sustained virologic response rates are seen with DAA agents in CKD populations. A thoughtful approach to the timing of treatment is required to facilitate timely access to kidney transplantation.
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| http://dx.doi.org/10.1097/MNH.0000000000000298 | DOI Listing |
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