Purpose: Multiple outcome measures exist to evaluate the outcomes of spinal decompression surgery; however, these tend to be complex and are difficult to express to the patient pre-operatively to accurately guide their expectations. We present outcomes, in terms of walking distance measurement, of a prospective single surgeon series of 76 consecutive patients with spinal stenosis.
Methods: 76 patients (mean age 68.8 years; 48-91 years) had decompression surgery using spinous process osteotomy. Accurate measurement of walking distance was used as an outcome measure, and factors that affect it were evaluated. Walking distance was measured pre-operatively, post-operatively and at 3 months follow-up using a measuring wheel. The minimum follow-up was 5 years.
Results: The mean distances walked were 78.1, 419.9 and 1285 m, respectively. Pre-operative disc height (p = 0.023) and male gender (p = 0.039) predicted a significant improvement in walking distance, while age (p = 0.23), ASA grade (p = 0.39) and the number of levels operated on (p = 0.89) did not significantly affect the increase in walking distance. 12 patients experienced post-operative complications (15.8%), and at last clinical follow-up (6.3 years, 5.1-6.9 years) 27 patients (35.5%) had residual leg symptoms and 8 had undergone further revision procedures (10.5%).
Conclusion: This study demonstrates that walking distance is an accurate and accessible method of determining surgical outcomes.
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http://dx.doi.org/10.1007/s00586-016-4881-x | DOI Listing |
J Appl Biomech
January 2025
Department of Health and Kinesiology, The University of Utah, Salt Lake City, UT, USA.
Shoes or insoles embedded with carbon fiber materials to increase longitudinal stiffness have been shown to enhance running and walking performance in elite runners, and younger adults, respectively. It is unclear, however, if such stiffness modifications can translate to enhanced mobility in older adults who typically walk with greater metabolic cost of transport compared to younger adults. Here, we sought to test whether adding footwear stiffness via carbon fiber insoles could improve walking outcomes (eg, distance traveled and metabolic cost of transport) in older adults during the 6-minute walk test.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of California Irvine, Irvine, CA, USA.
Background: Alterations to spatial navigation have been suggested by previous studies to represent an early cognitive marker for those with and at risk of Alzheimer's Disease (AD). However, with most of these studies focusing on spatial memory (usage of formed spatial representations), very little is known about the extent to which spatial exploration (process by which spatial representations are formed) may be altered in AD. The aim of this study is to investigate how spatial exploration behavior may be altered in individuals with and at risk of AD, and the extent to which individuals can be classified into their clinical status based on their exploration behavior.
View Article and Find Full Text PDFMol Ther
January 2025
Institute of Experimental Medicine CAS, Department of Neuroregeneration, Videnska 1083, 142 20, Prague, Czech Republic. Electronic address:
Neurons in the central nervous system (CNS) lose regenerative potential with maturity, leading to minimal corticospinal tract (CST) axon regrowth after spinal cord injury (SCI). In young rodents, knockdown of PTEN, which antagonises PI3K signalling by hydrolysing PIP3, promotes axon regeneration following SCI. However, this effect diminishes in adults, potentially due to lower PI3K activation leading to reduced PIP3.
View Article and Find Full Text PDFJ Chem Inf Model
January 2025
Department of Computer Science and Technology, Shantou University, Shantou 515063, China.
The human microbiota may influence the effectiveness of drug therapy by activating or inactivating the pharmacological properties of drugs. Computational methods have demonstrated their ability to screen reliable microbe-drug associations and uncover the mechanism by which drugs exert their functions. However, the previous prediction methods failed to completely exploit the neighborhood topologies of the microbe and drug entities and the diverse correlations between the microbe-drug entity pair and the other entities.
View Article and Find Full Text PDFFront Public Health
January 2025
Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Objectives: Type 2 diabetes (T2D) and prediabetes are associated with poor walking endurance, a marker of physical function. We aimed to examine the long-term effects of metformin or intensive lifestyle intervention in adults at high risk of T2D on their 6-min walk test (6MWT) performance.
Methods: Participants were randomized in the 3-year Diabetes Prevention Program (DPP) to one of the three groups: lifestyle intervention, metformin, or placebo, and were subsequently followed in the DPP Outcomes Study.
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