AI Article Synopsis
- - Sclerosing bone dysplasias are a group of disorders where osteoclasts fail to break down bone, causing dangerously high levels of bone mineral density (BMD).
- - Researchers treated three children with high BMD using acetazolamide to create metabolic acidosis, aiming to boost bone resorption and lower BMD.
- - All three patients responded well to the treatment, tolerating it without issues and showing satisfactory clinical improvement.
Article Abstract
Sclerosing bone dysplasias are a series of clinically and genetically heterogeneous diseases characterized by functional failure of the osteoclasts in bone resorption, leading to an excessive amount of bone mineral density (BMD) which could have serious clinical consequences. We treated three children affected with seriously high levels of BMD with acetazolamide, with the intention of inducing metabolic acidosis, thus increasing bone resorption and reducing BMD. All our patients tolerated and followed the treatment well and the clinical response was satisfactory in all cases.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116865 | PMC |
| http://dx.doi.org/10.5582/irdr.2016.01067 | DOI Listing |
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