AI Article Synopsis
- Multiple myeloma (MM) is a type of cancer that affects plasma cells, causing them to produce abnormal proteins, but skin issues are uncommon
- The study discusses four patients who initially showed skin conditions like leukocytoclastic vasculitis and pyoderma gangrenosum, which later led to a diagnosis of MM
- These patients didn't have typical symptoms like bone or kidney problems initially, but unusual symptoms and lack of response to standard treatments raised suspicion for MM, confirmed through specialized tests like serum immunoelectrophoresis and bone marrow biopsy
Article Abstract
Multiple myeloma (MM) is a proliferative disorder of plasma cells which produce abnormal immunoglobulin proteins. Skin involvement is rarely found in this disorder. They are either specific or nonspecific lesions. We report four such interesting patients who presented to us initially with common dermatoses such as leukocytoclastic vasculitis, pyoderma gangrenosum, and vesiculobullous disorders and were subsequently diagnosed to have MM. There were no skeletal involvements or renal function abnormality at the time of presentation. Unusual presentation, nonresponsiveness to conventional therapy, and abnormal blood parameters prompted us to suspect some underlying systemic conditions which were later confirmed to be MM after serum immunoelectrophoresis for M-band and bone marrow biopsy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122285 | PMC |
| http://dx.doi.org/10.4103/0019-5154.193682 | DOI Listing |
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