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Optic Neuritis: Another Dickensian Diagnosis.

Neuroophthalmology

November 2013

Department of Neurology, VU Medical Center, Amsterdam, The Netherlands; and Department of Neuroimmunology Laboratory, University College London Institute of Neurology London United Kingdom.

The clinical diagnosis and natural history of optic neuritis was established in the late 1880s by the ophthalmologists von Graefe and Nettleship. The earlier, accurate and insightful description of transient, bilateral visual loss of Esther, the main character in the Charles Dickens novel (1852--1853), suggests optic neuritis as a Dickensian diagnosis. Remarkably, Dickens' observations, also preceding the earliest clinical description of multiple sclerosis by Charcot in 1868, described many clinical features such as a prodromal phase; a nadir; gradual recovery over weeks; glare disability; reduced contrast sensitivity; possibly Uhthoff's phenomenon; and visual fading.

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The concept of hypomanic personality has historically been viewed with ambivalence. However, by replacing cyclothymic personality with cyclothymic disorder, DSM III doomed this entity into oblivion. The author examines the Dickensian portrayal of Mr.

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