The aim of this study was to evaluate the impact of dental caries, traumatic dental injuries (TDI), toothaches, and malocclusion on the oral health-related quality of life (OHRQoL) of the families of Brazilian preschool children. A population-based, matched case-control study involving 415 pre-schoolers aged 3-5 years was conducted. The case (impact on OHRQoL) and control groups (no impact on OHRQoL) were matched for age, gender, and family income at an 1:4 ratio. Impact on the OHRQoL of a family was assessed using the Brazilian version of the Early Childhood Oral Health Impact Scale (B-ECOHIS). Dental caries, TDI, and malocclusion were diagnosed by three calibrated dentists (Kappa: 0.85-0.90). Data analysis involved descriptive statistics and conditional logistic regression analysis (p ≤ 0.05; 95%CI). There were no differences between the cases and controls regarding age, gender, and family income (p > 0.05). The most frequent responses on the B-ECOHIS among cases were "felt guilty" (68.6%) and "been upset" (48.2%). The following variables were significantly associated with negative impacts on family OHRQoL (cases): caries severity (OR = 6.680; 95%CI = 2.731-16.349), a history of toothache (OR = 2.666; 95%CI = 1.492-4.765), parental rating of the child's oral health as poor (OR: 1.973; 95%CI = 1.072-3.634), and parent's/caregiver's age (OR = 2.936; 95%CI = 1.077-3.478). Anterior open bite was positively associated with OHRQoL (OR = 4.050; 95%CI = 1.333-12.314). Caries severity, a history of toothache, parental rating of the child's oral health as poor, and younger parents/caregivers were associated with impact on the OHRQoL of the families of preschoolers.
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http://dx.doi.org/10.1590/1807-3107BOR-2016.vol30.0121 | DOI Listing |
Am J Cancer Res
December 2024
Department of Thoracic Surgery, Akita University Graduate School of Medicine Akita 010-8543, Japan.
Poor oral health is an independent risk factor for upper-aerodigestive tract cancers, including esophageal squamous cell carcinoma (ESCC); thus, good oral health may reduce the risk of ESCC. We previously reported that high expression of Toll-like receptor (TLR) 6, which recognizes peptidoglycan (PGN) from Gram-positive bacteria correlates with a good prognosis after esophagectomy for ESCC. Most beneficial bacteria in the mouth are Gram-positive.
View Article and Find Full Text PDFAm J Cancer Res
December 2024
Department of Otorhinolaryngology, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital Yilan 265, Taiwan.
Betel nut chewing, common in several Asian populations, is linked to increased cancer risk, including oral, esophageal, gastric, and hepatocellular carcinoma. Aspirin shows potential as a chemopreventive agent. This study investigates the association between aspirin use and cancer risk among betel nut chewers.
View Article and Find Full Text PDFHeart Rhythm O2
December 2024
Cardiology Department, Health Sciences North Research Institute, Northern Ontario School of Medicine University, Sudbury, Ontario, Canada.
Background: There is consensus on the safety of standard dose direct oral anticoagulants (DOACs) for stroke prevention in patients undergoing cardioversion of atrial fibrillation (AF), but outcomes of reduced dose DOACs in this setting remain unclear.
Objective: This systematic review and meta-analysis aimed to compare the rate of cardioversion-associated thromboembolic events between patients taking reduced dose DOACs and those receiving standard dose anticoagulation.
Methods: A systematic search was conducted for studies published between January 1, 2009, and February 16, 2024 in PubMed, Embase, and Cochrane Central Register of Controlled Trials.
Ther Adv Neurol Disord
January 2025
Department of Medical and Surgical Sciences, University of Foggia, Foggia 71122, Italy.
Background: Characterizing Cladribine tablets prescription pattern in daily clinical practice is crucial for optimizing multiple sclerosis (MS) treatment.
Objectives: To describe efficacy, safety profile and new disease-modifying therapy (DMT) prescriptions following Cladribine treatment.
Design: Independent retrospective cohort study in patients followed at six Italian MS centres.
In 2019, diabetes mellitus affected 9.3% of the global population and accounted for one in nine adult deaths. Plant-based antioxidants neutralize harmful free radicals, mitigate oxidative stress, and significantly prevent diabetes and its complications.
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