AI Article Synopsis
- Metastasis in cutaneous melanoma occurs through complex interactions among tumor cells, host factors, and body mechanisms, with two main pathways: hematogenous (via blood) and lymphogenous (via lymph).
- Three models explain melanoma progression: stepwise spread, simultaneous spread, and differential spread, each with differing timelines for metastasis development.
- Key factors influencing melanoma progression include patient sex and the location of the primary tumor, and there is a need for more research on how tumor mutations affect metastatic pathways to improve patient risk assessment and tailored surveillance.
Article Abstract
Metastasis represents the end product of an elaborate biological process, which is determined by a complex interplay between metastatic tumour cells, host factors and homoeostatic mechanisms. Cutaneous melanoma can metastasize haematogenously or lymphogenously. The three predominant models that endeavour to explain the patterns of melanoma progression are the stepwise spread model, the simultaneous spread model and the model of differential spread. The time course to the development of metastases differs between the different metastatic routes. There are several clinical and histopathological risk factors for the different metastatic pathways. In particular, patient sex and the anatomical location of the primary tumour influence patterns of disease progression. There is limited existing evidence regarding the relationship between tumour mutation status, other diagnostic and prognostic biomarkers and the metastatic pathways of primary cutaneous melanoma. This knowledge gap needs to be addressed to better identify patients at high risk of disease recurrence and personalize surveillance strategies.
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| http://dx.doi.org/10.1111/pcmr.12544 | DOI Listing |
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