Recent studies have identified that CuS nanocrystal (CuS NCs) could be used as a new class of promising photo-thermal agents due to their excellent plasmonic absorption abilities in a wide near-infrared (NIR) region. However, most of nanocarriers lack target capacity for combining chemotherapy and photothermal therapy effects. Herein, we reported chitosan (CS)-encapsulated and folic acid (FA)-modified nanoparticles (NPs) simultaneously loading with functionalized CuS NCs and docetaxel (DTX) (FA-DTX-PVP/CuS-NPs). Compared with free DTX, the photothermal agent CuS NCs and DTX not only could be specially targeted to deliver into MCF-7 cancer cells via a receptor-mediated endocytosis pathway, but also could be effectively transferred into tumor tissues of S tumor-bearing mice in vivo. More important, when combination with NIR laser irradiation, FA-DTX-PVP/CuS-NPs showed a higher antitumor efficacy than the individual therapies. Thus, as a remote and noninvasive tumor therapy strategy, these active targeting NPs may provide a great potential for tumor synergistic therapy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/1061186X.2016.1266651 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Engineering hybrid CuS/CoS nanocages by ion reutilization for highly sensitive glucose sensing platforms.
Talanta
December 2024
College of Materials Science and Technology, Sichuan University, Chengdu, 610065, PR China; The Institute of Technological Sciences, Wuhan University, Wuhan, 430072, PR China. Electronic address:
Constructing hybrid hollow nano-electrocatalysts with various transition metal sulfides (TMSs) is highly desirable for sensitive enzyme-free glucose monitoring, but limited research has been conducted due to the constraints of current demanding synthesis technologies. In this study, we integrated CuS and CoS as hybrid nanocages (h-NCs) by advanced synthetic strategies, including coordinated etching and precipitation (CEP) and template ion reutilization. The resulting CuS/CoS h-NCs induced good synergistic effect in electrocatalytic activities, glucose adsorption, and electrical conductivity, as validated by the density functional theory (DFT) calculations.
View Article and Find Full Text PDFBaiting bacteria with amino acidic and peptidic corona coated defect-engineered antimicrobial nanoclusters for optimized wound healing.
Bioact Mater
December 2024
Department of Chemical and Biomolecular Engineering, Faculty of Engineering, National University of Singapore, Singapore, 117585, Singapore.
Article Synopsis
- Developing effective antibacterial strategies has become challenging due to bacterial resistance, prompting researchers to engineer copper sulfide nanoclusters (CuS NCs) with specific sulfur defects to enhance their effectiveness against bacterial infections.
- By encasing these CuS NCs in a mixture of amino acids and peptides, researchers improved the uptake of these nanoparticles by E. Coli, achieving an increase in uptake of at least 1.5-fold compared to traditional methods.
- The engineered CuS NCs demonstrate a synergistic effect in their bactericidal properties, benefiting from balanced photothermal and chemodynamic outcomes, while also being biodegradable and easy to clear after use.
Al-Doped CuS Colloidal Nanocrystals as a Highly Efficient Electrochemiluminescence Emitter for the Ultrasensitive Detection of Circulating Tumor DNA.
Anal Chem
September 2024
Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, Chongqing Engineering Laboratory of Nanomaterials & Sensor Technologies, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
Herein, CuS colloidal nanocrystals (NCs) with adjustable band gap and good film forming ability have been synthesized as new ECL materials. Furthermore, the band gap and oxygen vacancy (O) content of CuS NCs are regulated by Al doping, which significantly improves the ECL response of CuS NCs. First, the band gap of CuS-Al NCs decreases after doping with Al, which makes it easier for electrons to transition across the band gap.
View Article and Find Full Text PDFDitopic ligand effects on solution structure and redox chemistry in discrete [CuS] clusters with labile Cu-S bonds.
Nanoscale
August 2024
University of Minnesota - Twin Cities, Minneapolis, MN 55455, USA.
Copper chalcogenide nanoclusters (Cu-S/Se/Te NCs) are a broad and diverse class of atomically precise nanomaterials that have historically been studied for potential applications in luminescent devices and sensors, and for their beautiful, mineral-like crystal structures. By the "cluster-surface" analogy, Cu-S/Se NCs are prime candidates for the development of nanoscale multimetallic catalysts with atomic precision. However, the majority of studies conducted to date have focused exclusively on their solid-state structures and physical properties, leaving open questions as to their solution stability, dynamics, and reactivity.
View Article and Find Full Text PDFAn injectable hydrogel based on sodium alginate and gelatin treats bacterial keratitis through multimodal antibacterial strategy.
Int J Biol Macromol
August 2024
College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, China. Electronic address:
Bacterial keratitis is among the most prevalent causes of blindness. Currently, the abuse of antibiotics in clinical settings not only lacks bactericidal effects but also readily induces bacterial resistance, making the clinical treatment of bacterial keratitis a significant challenge. In this study, we present an injectable hydrogel (GS-PNH-FF@CuS/MnS) containing self-assembled diphenylalanine dipeptide (FF) and CuS/MnS nanocomposites (CuS/MnS NCs) that destroy bacterial cell walls through a synergistic combination of mild photothermal therapy (PTT), chemodynamic therapy (CDT), ion release chemotherapy, and self-assembled dipeptide contact, thereby eliminating Pseudomonas aeruginosa.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!