To accurately simulate therapeutic electron beams using Monte Carlo methods, backscatter from jaws into the monitor chamber must be accounted for via the backscatter factor, S . Measured and simulated values of S for the TrueBeam are investigated. Two approaches for measuring S are presented. Both require service mode operation with the dose and pulse forming networking servos turned off in order to assess changes in dose rate with field size. The first approach samples an instantaneous dose rate, while the second approach times the delivery of a fixed number of monitor units to assess dose rate. Dose rates were measured for 6, 12 and 20 MeV electrons for jaw- or MLC-shaped apertures between [Formula: see text] and [Formula: see text] cm. The measurement techniques resulted in values of S that agreed within 0.21% for square and asymmetric fields collimated by the jaws. Measured values of S were used to calculate the forward dose component in a virtual monitor chamber using BEAMnrc. Based on this forward component, simulated values of S were calculated and compared to measurement and Varian's VirtuaLinac simulations. BEAMnrc results for jaw-shaped fields agreed with measurements and with VirtuaLinac simulations within 0.2%. For MLC-shaped fields, the respective measurement techniques differed by as much as 0.41% and BEAMnrc results differed with measurement by as much as 0.4%, however, all measured and simulated values agreed within experimental uncertainty. Measurement sensitivity was not sufficient to capture the small backscatter effect due to the MLC, and Monte Carlo predicted backscatter from the MLC to be no more than 0.3%. Backscatter from the jaws changed the electron dose rate by up to 2.6%. This reinforces the importance of including a backscatter factor in simulations of electron fields shaped with secondary collimating jaws, but presents the option of ignoring it when jaws are retracted and collimation is done with the MLC.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1088/1361-6560/61/24/8779 | DOI Listing |
J Am Med Dir Assoc
January 2025
School of Pharmacy and Pharmacology, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, Australia.
Objectives: To investigate the rate of, and factors affecting, acceptance of pharmacists' recommendations by medical prescribers following medication reviews conducted in non-hospitalized older adults.
Design: A systematic review and meta-analysis with meta-regression.
Setting And Participants: Older adults (mean age ≥55 years) residing in the community or in aged care facilities (ie, non-hospitalized) who had received an individualized medication review by a pharmacist.
Mutat Res Rev Mutat Res
January 2025
Radiation Epidemiology Branch, National Cancer Institute, MD 20892-9778, USA; Faculty of Health, Science and Technology, Oxford Brookes University, Headington Campus, OX3 0BP, UK.
Biological effects of ionizing radiation vary with radiation quality, which is often expressed as the amount of energy deposited per unit length, i.e., linear energy transfer (LET).
View Article and Find Full Text PDFLancet Diabetes Endocrinol
January 2025
British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, UK. Electronic address:
Background: Data on the effect of mineralocorticoid receptor antagonist therapy on HbA levels and new-onset diabetes are conflicting. We aimed to examine the effect of oral finerenone, compared with placebo, on incident diabetes in the Finerenone Trial to Investigate Efficacy and Safety Superior to Placebo in Patients with Heart Failure (FINEARTS-HF) trial.
Methods: In this randomised, double-blind, placebo-controlled trial, 6001 participants with heart failure with New York Heart Association functional class II-IV, left ventricular ejection fraction 40% or higher, evidence of structural heart disease, and elevated N-terminal pro-B-type natriuretic peptide levels were randomly assigned to finerenone or placebo, administered orally.
Seizure
December 2024
Epilepsy Center, Medical Center, University of Freiburg, Breisacher Str. 64, 79106 Freiburg im Breisgau, Germany.
Purpose: To evaluate the efficacy of cenobamate (CNB) in adults with focal epilepsy based on the number of previous lifetime antiseizure medications (ASMs).
Methods: Twenty patients receiving add-on treatment with CNB with <6 lifetime ASMs were retrospectively compared to 20 Patients with >10 ASMs and approximately the same age. Efficacy was assessed at 3, 6, and 12 months following CNB initiation.
PM R
January 2025
Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota, USA.
Background: Individuals with spinal cord injury (SCI) commonly have autonomic dysreflexia (AD) with increased sympathetic activity. After SCI, individuals have decreased baroreflex sensitivity and increased vascular responsiveness.
Objective: To evaluate the relationship between baroreflex and blood vessel sensitivity with AD symptoms.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!