AI Article Synopsis
- The world population is expected to reach 9 billion by 2050, necessitating a 60% increase in food production, making insecticides crucial to prevent significant crop yield losses from pests.
- A new class of mesoionic compounds has been developed that shows strong insecticidal effects against certain pest groups by binding to key receptors in their nervous systems.
- Specific insecticides like Triflumezopyrim and Dicloromezotiaz have been highlighted for their effectiveness in controlling rice hoppers and lepidopteran pests, offering innovative solutions for agricultural challenges in Asia.
Article Abstract
Background: As the world population grows towards 9 billion by 2050, it is projected that food production will need to increase by 60%. A critical part of this growth includes the safe and effective use of insecticides to reduce the estimated 20-49% loss of global crop yields owing to pests. The development of new insecticides will help to sustain this protection and overcome insecticide resistance.
Results: A novel class of mesoionic compounds has been discovered, with exceptional insecticidal activity on a range of Hemiptera and Lepidoptera. These compounds bind to the orthosteric site of the nicotinic acetylcholine receptor and result in a highly potent inhibitory action at the receptor with minimal agonism. The synthesis, biological activity, optimization and mode of action will be discussed.
Conclusion: Triflumezopyrim insect control will provide a powerful tool for control of hopper species in rice throughout Asia. Dicloromezotiaz can provide a useful control tool for lepidopteran pests, with an underexploited mode of action among these pests. © 2016 Society of Chemical Industry.
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| http://dx.doi.org/10.1002/ps.4496 | DOI Listing |
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