AI Article Synopsis
- The study investigates the outcomes of splenectomy as a treatment for chronic immune thrombocytopenia purpura (ITP) at Aga Khan University Hospital, covering patients treated between 2005 and 2015.
- Of the 51 patients, 84.3% achieved a complete response to the surgery, with a low relapse rate of 8.8% after one year.
- Younger patients (under 50 years old) had a significantly lower failure rate of splenectomy compared to older patients, highlighting that younger age may predict better surgical outcomes.
Article Abstract
Immune thrombocytopenia purpura (ITP) may need splenectomy after failure of medical treatment. The aim of this study was to explore the outcome of splenectomy in chronic ITP and to point out factors which can predict better response to splenectomy. This retrospective chart review was conducted at the Aga Khan University Hospital, Karachi, and comprised adult patients who underwent splenectomy for ITP from October 2005 to December 2015. Of the 51 patients, 37(72.5%) were females and 14(27.5%) were males. The overall median age was 32 years (interquartile range: 18-65 years). Complete response was seen in 43(84.3%) patients, 2(4%) had response and 6(11.7%) had no response. Relapse rate of ITP at 1 year was 4(8.8%). Multivariate analysis showed that failure rate of splenectomy in the 41(80.4%) patients aged <50 years was 3(7%) as opposed to 3(30%) in the 10(19.6%) patients aged >50 years (p=0.04). Splenectomy was found to be a safe and effective option for treatment of ITP. Young age at the time of surgery was associated with good response to surgery.
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