IncP Plasmid Carrying Colistin Resistance Gene mcr-1 in Klebsiella pneumoniae from Hospital Sewage.

Antimicrob Agents Chemother

Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China

Published: February 2017

A Klebsiella pneumoniae strain of sequence type 313 (ST313) recovered from hospital sewage was found carrying the plasmid-borne colistin resistance gene mcr-1, which was bracketed by two copies of the insertion sequence ISApl1 on a 57-kb self-transmissible IncP-type plasmid of a new IncP-1 clade. The carriage of mcr-1 on a self-transmissible broad-host-range plasmid highlights that mcr-1 has the potential to spread beyond the Enterobacteriaceae family.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278755PMC
http://dx.doi.org/10.1128/AAC.02229-16DOI Listing

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