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Targeting CDK2 to circumvent treatment resistance in HR breast cancer.
Trends Mol Med
December 2024
Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA. Electronic address:
Genetic and epigenetic defects of the p53 system have previously been associated with resistance to CDK4/6 inhibitors in women with HR breast cancer. Recent data from Kudo et al. demonstrate that CDK2-targeting agents may offer an effective strategy to circumvent such resistance by enforcing cellular senescence downstream of RBL2 dephosphorylation.
View Article and Find Full Text PDFDreaming of being chased reflects waking-life experiences related to negative relationships with others metaphorically.
Front Psychol
July 2024
Institute of Analytical Psychology, City University of Macau, Macau, China.
Introduction: It has long been argued that there are dream metaphors which express waking-life experiences indirectly. Most of empirical evidence concerning this topic was in a qualitative way, while few studies explored the topic in a quantitative way. Under this background, we investigated whether dreaming of the typical theme 'being chased or pursued' was a metaphorical expression for waking-life experiences related to 'negative relationships with others'.
View Article and Find Full Text PDFREM sleep behavior disorder in Brunner syndrome.
J Clin Sleep Med
September 2024
Department of Neurology, Hospital Clínic de Barcelona, Barcelona, Spain.
Unlabelled: Brunner syndrome is a recessive X-linked disorder characterized by intellectual disability and impulsive aggressiveness associated with monoamine oxidase A (MAOA) deficiency leading to increased monoaminergic activity. We report the presence of rapid eye movement (REM) sleep behavior disorder in a 46-year-old patient with Brunner syndrome due to a c.1438A > G/iVS14-2 A > G mutation of the gene.
View Article and Find Full Text PDFVeterinarian-Chasing A Dream Job? A Comparative Survey on Wellbeing and Stress Levels among European Veterinarians between 2018 and 2023.
Vet Sci
January 2024
Federation of Veterinarians of Europe, Rue Victor Oudart 7, 1030 Brussels, Belgium.
Article Synopsis
- - A study of veterinarians in Europe revealed ongoing mental wellbeing issues, influenced by socio-economic and cultural factors, despite the profession's positive aspects.
- - Surveys conducted in 2018/2019 and 2022/2023 assessed stress, medical leave needs, and mental wellbeing, highlighting that early-career and female veterinarians faced greater challenges.
- - Results showed consistently high stress levels and low mental wellbeing scores, indicating an urgent need for improvements in workplace support, work/life balance, and job satisfaction in the veterinary field.
The relationship between typical dreams and mental health of residents in village-in-city.
Sleep Med X
December 2023
Department of Adolescent Mental Health, Mental Hospital, Xi'an International Medical Center Hospital of Northwest University, Xi'an, 710119, China.
Aim: This study aimed to explore the relationship between typical dreams and the mental health of residents in village-in-city.
Methods: This study used the Chinese version of the Typical Dreams Questionnaire and Symptom Checklist 90 (SCL-90) to investigate the mental health status and typical dream themes of 1,190 residents recruited through random sampling from a village-in-city in Xi'an. Correlation analysis, -test, and binary regression analysis were performed on the data using SPSS 24.
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