Essential Oil Lacks Mutagenic Activity in the /Microsome and Micronucleus Assays.

ScientificWorldJournal

Programa de Pós-Graduação em Ciências Veterinárias, UFRGS, Porto Alegre, RS, Brazil; Laboratório de Produtos Naturais/Fitoquímica-Farmacologia e Toxicologia Veterinária, Departamento de Farmacologia, UFRGS, Porto Alegre, RS, Brazil; Programa de Pós-Graduação em Farmacologia e Terapêutica, UFRGS, Porto Alegre, RS, Brazil.

Published: November 2017

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The present study aimed to investigate the mutagenic activity of essential oil. The most abundant compounds identified by GC-MS were -terpinene (25.73%), -terpinene (17.35%), terpinen-4-ol (17.24%), and sabinene (10.8%). Mutagenicity was evaluated by the /microsome test using the preincubation procedure on TA98, TA97a, TA100, TA102, and TA1535 strains, in the absence or in the presence of metabolic activation. Cytotoxicity was detected at concentrations higher than 0.04 L/plate in the absence of S9 mix and higher than 0.08 L/plate in the presence of S9 mix and no gene mutation increase was observed. For the mammalian cell micronucleus test, V79 Chinese hamster lung fibroblasts were used. Cytotoxicity was only observed at concentrations higher than or equal to 0.05 g/mL. Moreover, when tested in noncytotoxic concentrations, essential oil was not able to induce chromosome mutation. The results from this study therefore suggest that essential oil is not mutagenic at the concentrations tested in the /microsome and micronucleus assays.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116495PMC
http://dx.doi.org/10.1155/2016/3694901DOI Listing

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