Bowen's disease (BD) is a form of squamous cell carcinoma often associated with human papillomavirus. Co-infection with human immunodeficiency virus (HIV) is associated with a greater risk of malignancy. We describe a case of BD in a 52-year-old unmarried HIV-positive male who presented with extensive skin lesions of 1-year duration. Histopathology was suggestive of BD. He had been tried with topical imiquimod cream and cryo-therapy for 6 months. We observed no response for these above therapies. He was started on with anti-retroviral therapy (ART) as his CD4 count was 253 cells/mm. The entire cutaneous lesions completely disappeared within 6 months of ART, which was an interesting incidence.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111310 | PMC |
| http://dx.doi.org/10.4103/0253-7184.192123 | DOI Listing |
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- The article presents a clinical case of a young patient with HPV-associated penile intraepithelial neoplasia (PIN), specifically the erythematous form of bowenoid papulosis.
- It highlights the issues of delayed diagnosis due to improper diagnostic approaches and a lack of awareness among doctors about cancer-related diseases.
- The piece emphasizes the significance of early detection in preventing progression to more severe conditions like squamous cell penile carcinoma, detailing the different subtypes of PIN and their varying risks of leading to cancer.
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