AI Article Synopsis
- PML is a rare and usually deadly brain infection caused by the reactivation of the John Cunningham virus, primarily affecting people with weakened immune systems.
- There is growing recognition that PML can present in various ways, which is important for developing effective treatments.
- Rheumatologists need to be more aware of PML to ensure earlier diagnosis and possible immune recovery, potentially improving patient outcomes.
Article Abstract
Progressive multifocal leukoencephalopathy (PML) is a rare, typically fatal, demyelinating central nervous system infection caused by reactivation of the John Cunningham virus that generally occurs in immunosuppressed patients. With an evolving understanding of a greater clinical heterogeneity of PML and significant implications for therapy, PML should be considered in the differential diagnosis of neurologic presentations of rheumatic diseases. Increased awareness of PML among rheumatologists is required, as earlier diagnosis and restoration of immune function may improve the otherwise grim prognosis associated with PML.
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| http://dx.doi.org/10.1016/j.rdc.2016.09.009 | DOI Listing |
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