Increasing evidence has accrued which indicates that mesenchymal stem cells (MSCs) have a potential clinical value in the treatment of certain diseases. Globally, nonalcoholic steatohepatitis (NASH) is a widespread disorder. In the present study, MSCs were isolated successfully from compact bone and a mouse model of NASH was established as achieved with use of a methionine-choline deficient (MCD) diet. Compact bone-derived MSCs transplantation reduced MCD diet-induced weight loss, hepatic lipid peroxidation, steatosis, ballooning, lobular inflammation and fibrogenesis. It was shown that MSCs treatment hampered MCD diet-induced proliferation of CD4 IFN-γ and CD4IL-6 T spleen cells. In addition, CD4IL-17 lymphocytes that associated with anti-inflammation show little change in MCD as well as in MCD+MSCs splenocytes. We conclude that MSCs may have a potential clinical value upon NASH, through their capacity to suppress activation of CD4 IFN-γ and CD4IL-6 lymphocytes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.intimp.2016.11.012 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Vertical ridge augmentation using deproteinized bovine bone material without covering with a membrane: a tunnel pouch technique- 4-year follow-up- A pilot clinical study.
J Oral Implantol
December 2024
MDS, Specialist, Brånemark Osseointegration Center India, No-3, 21st main, Vijaynagar, Bengaluru- 560040.
Purpose Of The Study-: The present pilot clinical trial was planned to evaluate the effect of particulate deproteinized bovine bone graft mixed with blood could be used as a vertical ridge augmentation material without covering with any form of collagen membrane in a tunnel pouch technique, resulting in sufficient bone formation to allow placement of dental implants, with maintenance of the newly formed bone after final restoration.
Material And Methods—: Eight patients (three males and five females) were selected for this procedure and treated between February 2016 and December 2017. All these patients had a deficient vertical height of the posterior mandibular alveolar bone above the inferior alveolar canal.
MSCs alleviate LPS-induced acute lung injury by inhibiting the proinflammatory function of macrophages in mouse lung organoid-macrophage model.
Cell Mol Life Sci
March 2024
State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Rd, Hangzhou, 310003, China.
Acute lung injury (ALI) is an inflammatory disease associated with alveolar injury, subsequent macrophage activation, inflammatory cell infiltration, and cytokine production. Mesenchymal stem cells (MSCs) are beneficial for application in the treatment of inflammatory diseases due to their immunomodulatory effects. However, the mechanisms of regulatory effects by MSCs on macrophages in ALI need more in-depth study.
View Article and Find Full Text PDFA pedagogical approach for the development and optimization of a novel mix of biowastes-derived hydroxyapatite using the Box-Behnken experimental design.
Heliyon
January 2024
Department of Mechanical Engineering, Ahmadu Bello University, Zaria, 810222, Kaduna State, Nigeria.
The current study details the creation of synthetic hydroxyapatite (HAp) using a combination of catfish and bovine bones (C&B). This is done to design the optimum processing parameters and consolidate instructional strategies to develop HAp scaffolds for biomedical engineering. The HAp produced from the novel mix of the biogenic materials (C&B) was through calcination and supported with the sol-gel technique, sintering, and low-cold compaction pressure.
View Article and Find Full Text PDFHistological and Immunological Evaluation of the Osteogenic Effects of Compact Bone-Delivered Stem Cell on Spongiosis Bone in the Rat Zygomatic Arch Defect Model.
Ann Plast Surg
September 2023
Bagcılar Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Background: In stem cell applications, apart from bone marrow and adipose tissue, compact bone is also used as an alternative. However, studies on this subject are limited. In our study, we investigated the effect of stem cell derived from compact bone on rat zygomatic arch defect.
View Article and Find Full Text PDFDistinct genomic routes underlie transitions to specialised symbiotic lifestyles in deep-sea annelid worms.
Nat Commun
May 2023
School of Biological and Behavioural Sciences, Queen Mary University of London, Mile End Road, E1 4NS, London, UK.
Bacterial symbioses allow annelids to colonise extreme ecological niches, such as hydrothermal vents and whale falls. Yet, the genetic principles sustaining these symbioses remain unclear. Here, we show that different genomic adaptations underpin the symbioses of phylogenetically related annelids with distinct nutritional strategies.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!