A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 176

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML

File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

IL-17 protein levels in both induced sputum and plasma are increased in stable but not acute asthma individuals with obesity. | LitMetric

AI Article Synopsis

  • Obesity worsens asthma control due to various factors, including increased airway neutrophils and comorbidities like sleep apnea and depression, and IL-17 may play a role in these effects.
  • In a study of both stable and acute asthma patients, researchers found that obese subjects had higher IL-17 levels and airway neutrophilia, with these factors linked to depressive symptoms.
  • While IL-17 levels were higher in acute asthma patients compared to stable ones, overall effects of obesity on acute asthma remain unclear, suggesting that IL-17 contributes to poor disease control in obese asthmatics.

Article Abstract

Background: Obesity worsens asthma control partly through enhanced airway neutrophilia, altered lung mechanics and comorbidities, including obstructive sleep apnea syndrome, gastroesophageal reflux disease and depression. Although controversial, obesity may also cause poorer outcomes in acute asthma. IL-17 is associated with neutrophilic inflammation, steroid resistance and severe asthma, but its importance in the association between asthma and obesity is unknown.

Objective: To investigate the role of IL-17 in obese asthma in both acute and stable settings.

Methods: Both stable (n = 177) and acute (n = 78) asthmatics were recruited and categorized into lean (n = 77 and 39 respectively), overweight (n = 41 and 17 respectively) and obese (n = 59 and 22 respectively) groups and compared for clinical characteristics, including sputum and plasma IL-17 protein concentrations, sputum cellularity, spirometry and comorbidities. Correlations of IL-17 expression with other measures were explored.

Results: In stable subjects, airway neutrophilia and IL-17 concentrations were most prominent in the obese, and correlated positively with each other. Significant increase in plasma IL-17 levels was also noted and associated with elevated depressive symptoms in obesity. In acute asthma, IL-17 expression, like most other clinical measures, was similar among lean, overweight and obese groups, but was higher in acute versus stable asthma subjects, with sputum IL-17 correlating positively with sputum neutrophils and negatively with FEV and plasma IL-17 showing a positive connection to airway eosinophilia during exacerbation.

Conclusions: IL-17 contributes to worse disease control in obese asthma through enhancing airway neutrophilia and depression, and may implicate in asthma exacerbations. Effects of adiposity on acute asthma remain uncertain.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rmed.2016.10.018DOI Listing

Publication Analysis

Top Keywords

acute asthma
16
airway neutrophilia
12
plasma il-17
12
il-17
11
asthma
11
il-17 protein
8
sputum plasma
8
asthma il-17
8
obese asthma
8
il-17 expression
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!