Purpose: To improve the stability of pectin-oligochitosan hydrogel microcapsules under physiological conditions.
Methods: Two different approaches were examined: change of the cross-linker length and treatment of the hydrogel microcapsules with 150 Mm CaCl2. Replacement of pectin with alginate was also studied.
Results And Conclusions: It was observed that the molecular weight of the cross-linker oligochiotsan had no significant improvement on microcapsule stability. On the other hand, the treatment of pectin-oligochitosan microcapsules with Ca2+ increased the microcapsule stability significantly. Different types of alginate were used; however, no red-blood-cell-shaped microcapsules could be produced, which is likely due to the charge-density difference between deprotonated pectin and alginate polymers.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.5301/ijao.5000532 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Biomimetic Vascularized iPSC-Hepatocyte Spheroids for Liver Regeneration.
Adv Sci (Weinh)
December 2024
Division of Hepatobiliary and Transplantation Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China.
Human induced pluripotent stem cell derived hepatocytes (hiPSC-heps) hold promising value for acute liver failure (ALF) treatment, while their therapeutic efficacy is usually limited by low cell bioactivity and untargeted in vivo accumulation. Here, inspired by vascularity supporting cellular architectures in the tissues and organs, a novel vascularized hiPSC-heps spheroid based on microfluidic microcapsules is presented for liver repair via orthotopic transplantation. The microcapsules are comprised of aqueous cores that facilitate hiPSC-hep aggregating into spheroids, and hybrid hydrogel shells of sodium alginate and hyaluronic acid methacryloyl (HAMA).
View Article and Find Full Text PDFThe inflammatory bowel disease and gut microbiome are restored by employing metformin-loaded alginate-shelled microcapsules.
J Control Release
December 2024
Major of Human Bio-convergence, Division of Smart Healthcare, Pukyong National University, Busan 48513, Republic of Korea. Electronic address:
Inflammatory bowel disease (IBD) is a chronic or recurrent inflammatory disorder affecting various parts of the gastrointestinal tract. Metformin, a widely prescribed hypoglycemic drug for type 2 diabetes, has shown potential in reducing IBD risk. However, its oral administration faces significant challenges due to the harsh gastrointestinal environment, requiring higher or more frequent doses to achieve therapeutic effects, which increases the risk of side effects.
View Article and Find Full Text PDFRecent Advances in 4D Printing: A Review of Current Smart Materials, Technologies, and Drug Delivery Systems.
Curr Pharm Des
December 2024
Institute of Pharmaceutical Research, GLA University, Mathura-Delhi Road, Mathura-281406, Uttar Pradesh, India.
Research on shape memory materials (SMM) or smart materials, along with advancements in printing technology, has transformed three-dimensional (3D) printing into what we now refer to as 4D printing. In this context, the addition of time as a fourth dimension enhances 3D printing. 4D printing involves the creation of 3D-printed objects that can change their shapes into complex geometries when influenced by external stimuli such as temperature, light, or pH over time.
View Article and Find Full Text PDFFunctionalized Nanozyme Microcapsules Targeting Deafness Prevention via Mitochondrial Homeostasis Remodeling.
Adv Mater
December 2024
Department of Otorhinolaryngology Head and Neck Surgery, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, 225001, China.
Mitochondrial dysfunction, which is the primary mechanism underlying cisplatin-induced hearing loss, can potentially be mitigated by modulating the redox balance and reprogramming the energy metabolism to remodel mitochondrial homeostasis. Herein, N-acetyl-l-cysteine-derived carbonized polymer dots (NAC CPDs) are embedded into manganese porphyrin-doped metal-organic frameworks and encapsulated using a polydopamine (PDA) coating and gelatin methacryloyl (GelMA) hydrogel to afford functionalized nanozyme microcapsules. Owing to their injectability and adhesion properties, these microcapsules exhibit the advantages of prolonged retention in the middle ear and sustained release in the inner ear.
View Article and Find Full Text PDFPreparation and properties of β-carotene-loaded sanxan emulsion gel microcapsules.
Int J Biol Macromol
December 2024
Tianjin Key Laboratory of Intelligent Breeding of Major Crops, Tianjin 300392, China; Tianjin Agricultural University, Tianjin 300392, China. Electronic address:
Sanxan has important application value in the field of bioactive substance delivery. However, the current sanxan emulsion gel method has certain limitations in delivering heat-sensitive lipophilic bioactive substances. In this study, the acid-gelling properties of sanxan were utilized to prepare sanxan emulsion gel microcapsules (SEGMs) by extrusion dripping method.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!