AI Article Synopsis
- - Over the last 30 years, progress in regenerative cell-based therapies for neurodegenerative diseases, especially Parkinson's, has been notable, yet challenges remain, such as ethical issues and risks of immune rejection and tumor development.
- - Fetal ventral mesencephalon grafts have shown success in preclinical trials, prompting clinical trials that demonstrate their effectiveness in certain cases.
- - There's a growing interest in using stem cell-derived dopaminergic neurons for future clinical applications, with trials expected to start in the next few years.
Article Abstract
Over the past three decades, significant progress has been made in the development of potential regenerative cell-based therapies for neurodegenerative disease, with most success being seen in Parkinson's disease. Cell-based therapies face many challenges including ethical considerations, potential for immune-mediated rejection with allogeneic and xenogeneic tissue, pathological spread of protein-related disease into the grafted tissue as well as the risk of graft overgrowth and tumorigenesis in stem cell-derived transplants. Preclinical trials have looked at many tissue types of which the most successful to date have been those using fetal ventral mesencephalon grafts, which led to clinical trials, which have shown that in some cases they can work very well. With important proof-of-concept derived from these studies, there is now much interest in how dopaminergic neurons derived from stem cell sources could be used to develop cell-based therapies suitable for clinical use, with clinical trials poised to enter the clinic in the next couple of years.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221268 | PMC |
| http://dx.doi.org/10.2217/rme-2016-0102 | DOI Listing |
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