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Oscillometry Assesses Small Airway Disease and Reveals Peripheral Lung Pathology in Early Pulmonary Fibrosis: A Cross-Sectional Study.
Diagnostics (Basel)
December 2024
Respiratory Medicine Department, University of Ioannina, 45110 Ioannina, Greece.
Small airway disease/dysfunction (SAD) is crucial in obstructive airway diseases but is less investigated in interstitial lung disease (ILD). There are only a few physiological studies investigating SAD in the context of pulmonary fibrosis. Oscillometry is a simple technique that assesses SAD with minimal patient effort.
View Article and Find Full Text PDFAscertainment of small airway dysfunction using oscillometry to better define asthma control and future risk: are we ready to implement it in clinical practice?
Chest
December 2024
Children's Hospital of Orange County, University California, Irvine, Orange County, Calif.
The small airways comprise generations 8 to 23 of the bronchial tree, consist of airways with an internal diameter <2mm, and are classically difficult to assess and treat in persistent asthma. Small airways dysfunction (SAD) is integral to the asthma management paradigm as it is associated with poorer symptom control, greater levels of type 2 inflammation, and has been proposed as a potential treatable asthma trait. Although identification of SAD by oscillometry has been found to be clinically useful in managing asthma, very few physicians, including specialists, use this technique as part of standard or adjunct evaluation of lung function to diagnose asthma, grade severity of airway obstruction, ascertain disease control or the risk for future exacerbations or to make management decisions.
View Article and Find Full Text PDFThe assessment of dupilumab in children with moderate-to-severe asthma and comorbid type 2 inflammatory diseases.
BMC Pulm Med
December 2024
Department of respiratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Background: Dupilumab inhibiting the signaling of interleukin(IL)-4 and IL-13 was recommended for the treatment of severe asthma in children ≥ 6 years old according to the Global Initiative for Asthma (GINA,2024).This study aimed to analyse the efficacy and safety of dupilumab in paediatric patients with moderate-to-severe asthma and comorbid type 2 inflammatory disease in a real-world population.
Methods: We evaluated the medical records of paediatric patients with moderate-to-severe asthma and comorbid type 2 inflammatory diseases, such as atopic dermatitis (AD) and allergic rhinitis (AR), receiving dupilumab treatment.
Mendelian randomization analysis of two samples to determine the impact of immune cells on bronchitis.
Medicine (Baltimore)
November 2024
The Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, Jilin Province, China.
Bronchitis is a common respiratory disease characterized by acute inflammation, edema, and necrosis of the small airways, leading to a significant pathological burden. Immune cells play a crucial role in combating bronchitis. This study aims to explore the causal relationship between immune cells and bronchitis using the Mendelian randomization approach.
View Article and Find Full Text PDFOscillometry-defined small airways dysfunction as a treatable trait in asthma.
Ann Allergy Asthma Immunol
November 2024
University of Dundee School of Medicine, Dundee, United Kingdom. Electronic address:
Article Synopsis
- * The oscillometry technique helps measure airflow resistance and reactance during normal breathing, providing insights into airway function.
- * A new management approach focuses on "treatable traits" to customize asthma treatment by identifying and addressing factors that affect control, including small airways dysfunction and the effectiveness of specific medications.
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