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An Overlap of Anticoagulant-Related and IgA Nephropathy: A Case Report.

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Department of Pathology Arkana Lab Little Rock, Little Rock, AR, USA.

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  • Anticoagulant-related nephropathy (ARN) is becoming more recognized as a cause of acute kidney injury (AKI), especially in patients using warfarin, and now also needs scrutiny for direct oral anticoagulants (DOACs).
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Anticoagulant related nephropathy (ARN) is the result of glomerular hemorrhage in patients on systemic anticoagulation therapy or underlying coagulopathy. Red blood cells (RBC) that passed through the glomerular filtration barrier form RBC casts in the tubules, increase oxidative stress and result in acute tubular necrosis (ATN). The mechanisms of ARN still not completely discovered.

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Background: AF is a global health concern, with systemic complications including renal dysfunction. This systematic review and meta-analysis compares the effects of rivaroxaban, a Factor Xa inhibitor, and vitamin K antagonists (VKAs) on renal outcomes in AF patients.

Methods: The study protocol is registered in PROSPERO (ID: CRD42023462756).

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