Background: The prognostic value of high-sensitivity troponin T (hs-TnT) elevation after elective percutaneous coronary intervention (PCI) in patients with or without raised baseline hs-TnT levels is unclear.
Objectives: The goal of this study was to assess whether the prognostic value of post-procedural hs-TnT level after elective PCI depends on the baseline hs-TnT level.
Methods: This study included 5,626 patients undergoing elective PCI who had baseline and peak post-procedural hs-TnT measurements available. The primary outcome was 3-year mortality (with risk estimates calculated per SD increase of the log hs-TnT scale).
Results: Patients were divided into 4 groups: nonelevated baseline and post-procedural hs-TnT levels (hs-TnT ≤0.014 μg/l; n = 742); nonelevated baseline but elevated post-procedural hs-TnT levels (peak post-procedural hs-TnT >0.014 μg/l; n = 2,721); elevated baseline hs-TnT levels (hs-TnT >0.014 μg/l) with no further rise post-procedure (n = 516); and elevated baseline hs-TnT levels with a further rise post-procedure (n = 1,647). A total of 265 deaths occurred: 6 (1.6%) in patients with nonelevated baseline and post-procedural hs-TnT levels; 54 (3.8%) in patients with nonelevated baseline but elevated post-procedural hs-TnT levels; 50 (16.0%) in patients with elevated baseline hs-TnT levels with no further rise post-procedure; and 155 (18.2%) in patients with elevated baseline hs-TnT levels with a further rise post-procedure (p < 0.001). After adjustment, baseline hs-TnT levels (hazard ratio [HR]: 1.22; 95% confidence interval [CI]: 1.09 to 1.38; p < 0.001) but not peak post-procedural hs-TnT levels (HR: 1.04; 95% CI: 0.85 to 1.28; p = 0.679) were associated with an increased risk of mortality. Peak post-procedural hs-TnT findings were not associated with mortality in patients with nonelevated (HR: 0.93; 95% CI: 0.69 to 1.25; p = 0.653) or elevated (HR: 1.24; 95% CI: 0.91 to 1.69; p = 0.165) baseline hs-TnT levels.
Conclusions: In patients with coronary artery disease undergoing elective PCI, an increase in post-procedural hs-TnT level did not offer prognostic information beyond that provided by the baseline level of the biomarker.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jacc.2016.08.059 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cardiac Damage in Patients Infected with Different SARS-CoV-2 Variants of Concern.
Microorganisms
December 2024
Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Coronavirus Disease 2019 causes significant morbidity, and different variants of concern (VOCs) can impact organ systems differently. We conducted a single-center retrospective cohort analysis comparing biomarkers and clinical outcomes in hospitalized patients infected with the wild-type or Alpha (wt/Alpha) VOC against patients infected with the Omicron VOC. We included 428 patients infected with the wt/Alpha VOC and 117 patients infected with the Omicron VOC.
View Article and Find Full Text PDFOptimized monitoring for immune checkpoint inhibitor induced myocarditis using high-sensitivity troponin-T.
Eur J Cancer
December 2024
Department of Dermatology and Allergy, University Hospital, LMU Munich, Munich, Germany; Department of Dermatology, Friedrich-Alexander University Erlangen-Nürnberg (FAU) and University Hospital Erlangen (UKER), Deutsches Zentrum Immuntherapie (DZI) and Comprehensive Cancer Center Erlangen-European Metropolitan Area of Nürnberg (CCC-ER-EMN), Erlangen, Germany; SERIO Registry (www.serio-registry.org), Germany. Electronic address:
Background: Immune checkpoint inhibitor (ICI)-induced Myocarditis (irMyocarditis) is a rare adverse event with a high mortality rate of 40-50 % and which is mostly not diagnosed until clinical symptoms emerge.
Objectives: This study aims to screen patients for irMyocarditis using high-sensitivity cardiac troponin-T (hs-TnT) before and regularly during therapy with ICI.
Methods: A cohort of 280 cancer patients were prospectively screened for levels of hs-TnT at baseline and prior to every ICI infusion.
High NT pro-BNP levels in children with malignant disorder receiving intensive fluid treatment: a prospective comparative study.
Front Pediatr
November 2024
Department of Pediatrics, Haemato-Oncology and Gastroenterology, Pomeranian Medical University, Szczecin, Poland.
Hematologic malignancies are a well-known risk factor for cardiovascular disease development. Chemotherapeutic protocols commonly include intensive fluid therapy (IFT), which may negatively influence the cardiovascular system and predispose to arterial hypertension. This study aims to evaluate atrial natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), and changes in blood pressure in children with hematological malignancies undergoing intensive fluid therapy.
View Article and Find Full Text PDFEndothelial activation, Cell-Cell Interactions, and Inflammatory Pathways in Postoperative Atrial Fibrillation Following Cardiac Surgery.
Biomed J
November 2024
Department of Cardiology, Hospital Clínico Universitario Virgen de la Arrixaca, University of Murcia, Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), CIBERCV, Murcia, Spain.
Article Synopsis
- This study investigates the link between endothelial activation and systemic inflammation in patients undergoing cardiac surgery, focusing on how these factors contribute to postoperative atrial fibrillation (POAF).
- Researchers compared 117 patients, including those with permanent AF and POAF, measuring various biological markers and cellular expressions related to heart function and inflammation.
- Findings indicate that both permanent AF and POAF patients exhibited higher signs of inflammation and endothelial activation, which may lead to atrial remodeling and increased risk of AF compared to non-AF patients.
High-sensitivity cardiac troponin-T concentrations and their prognostic implications in patients with paroxysmal supraventricular tachycardia.
Int J Cardiol
February 2025
Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Article Synopsis
- The study aimed to determine if high levels of high-sensitivity troponin-T (hs-TnT) in patients with paroxysmal supraventricular tachycardia (PSVT) but no known cardiovascular disease increase the risk of death.
- Researchers reviewed data from 1,203 patients hospitalized from 2013 to 2020, finding that 65.8% had elevated hs-TnT levels.
- Results showed significantly higher short-term mortality (within 30 days) for patients with elevated hs-TnT, but long-term mortality (31-365 days) differences were not significant and may need further study.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!