AI Article Synopsis
- The study investigates how genetic variations in metabolism and transport genes could impact the risk and prognosis of castration-resistant prostate cancer (CRPC).
- Researchers tested 634 different genotypes in 74 patients, using a specialized genotyping platform.
- While no genetic variations were linked to the risk of developing CRPC, three specific SNPs were significantly associated with better or worse prognosis among Caucasian patients.
Article Abstract
Aim: Metabolism and transport play major roles in life-long exposure to endogenous and exogenous carcinogens. We therefore explored associations between polymorphisms in absorption, distribution, metabolism and elimination genes and the risk and prognosis of castration-resistant prostate cancer (CRPC).
Materials & Methods: A total of 634 genotypes were tested in 74 patients using the Affymetrix DMETv1.0 platform.
Results: No relation to risk was found. Three SNPs were associated with CRPC prognosis in Caucasians: ABCB11 rs7602171G>A (p = 0.003; n = 30; hazard ratio [HR]: 0.307), GSTP1 rs1799811C>T (p = 0.001; n = 38; HR: 0.254) and SLC5A6 rs1395 (p = 0.004; n = 35; HR: 3.15). Two other polymorphisms among Caucasians were associated with interesting trends: ABCB4 rs2302387C>T (p = 0.039) and ABCC5 rs939339A>G (p = 0.018).
Conclusion: This exploratory study is the first to show that polymorphisms in several absorption, distribution, metabolism and elimination genes may be associated with CRPC prognosis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558514 | PMC |
| http://dx.doi.org/10.2217/pgs-2016-0134 | DOI Listing |
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