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Safety, Tolerability, and Pharmacokinetics of a Novel Anti-obesity Agent, S-309309, in Healthy Adults with or Without Obesity.
Clin Drug Investig
January 2025
Medical Science Department, Shionogi & Co., Ltd., Osaka, Japan.
Background: Anti-obesity medications are recommended for patients who do not achieve and maintain weight loss despite lifestyle interventions. S-309309 is a novel oral inhibitor of monoacylglycerol O-acyltransferase 2 being developed as a treatment for obesity.
Objective: The objective of the study was to investigate the safety, clinical pharmacology, pharmacokinetics and pharmacodynamic biomarker of S-309309.
Photosynthesis-Inspired NIR-Triggered Fe₃O₄@MoS₂ Core-Shell Nanozyme for Promoting MRSA-Infected Diabetic Wound Healing.
Adv Healthc Mater
January 2025
National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
Bacterial infections can lead to severe medical complications, including major medical incidents and even death, posing a significant challenge in clinical trauma repair. Consequently, the development of new, efficient, and non-resistant antimicrobial agents has become a priority for medical practitioners. In this study, a stepwise hydrothermal reaction strategy is utilized to prepare FeO@MoS core-shell nanoparticles (NPs) with photosynthesis-like activity for the treatment of bacterial infections.
View Article and Find Full Text PDFHierarchical MoS@NiFeCo-Mo(doped)-Layered Double Hydroxide Heterostructures as Efficient Alkaline Water Splitting (Photo)Electro-catalysts.
Small
January 2025
Department of Chemistry, Nanoscience Center, University of Jyväskylä, P.O. Box 35, Jyväskylä, FI-40014, Finland.
Designing cost-effective electrocatalysts with fast reaction kinetics and high stability is an outstanding challenge in green hydrogen generation through overall water splitting (OWS). Layered double hydroxide (LDH) heterostructure materials are promising candidates to catalyze both oxygen evolution reaction (OER) and hydrogen evolution reaction (HER), the two OWS half-cell reactions. This work develops a facile hydrothermal route to synthesiz hierarchical heterostructure MoS@NiFeCo-LDH and MoS@NiFeCo-Mo(doped)-LDH electrocatalysts, which exhibit extremely good OER and HER performance as witnessed by their low IR-corrected overpotentials of 156 and 61 mV with at a current density of 10 mA cm under light assistance.
View Article and Find Full Text PDFFirst-in-Human clinical trial of a small molecule EBNA1 inhibitor, VK-2019, in patients with Epstein-Barr positive nasopharyngeal cancer, with pharmacokinetic and pharmacodynamic studies.
Clin Cancer Res
January 2025
The Wistar Institute, Philadelphia, PA, United States.
Purpose: A first-in-human phase one study was conducted in nasopharyngeal carcinoma (NPC) patients to assess the safety and tolerability of VK-2019, a small molecule selective inhibitor of Epstein-Barr virus Nuclear Antigen 1 (EBNA1).
Patients And Methods: Pharmacokinetic and pharmacodynamic studies, including circulating tumor EBV DNA plasma levels, were performed. Twenty-three patients received VK-2019 orally once daily at doses ranging from 60 to 1800 mg using an accelerated titration design, with cohort expansion at 1800 mg.
Adaptive hybrid ANFIS-PSO and ANFIS-GA approach for occupational risk prediction.
Int J Occup Saf Ergon
January 2025
Computer Science Department; Badji Mokhtar University, Algeria.
This study attempted to optimize the adaptive neuro-fuzzy inference system (ANFIS) using particle swarm optimization (PSO) and a genetic algorithm (GA) for calculating occupational risk. Numerous studies have shown that the ANFIS is a good approach for predicting engineering problems. However, it is not well investigated in the area of risk assessment.
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