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Background: The cause of chronic thromboembolic pulmonary hypertension (CTEPH) remains largely unknown. Recently, clonal hematopoiesis (CH) has been reported to be associated with cardiovascular and thromboembolic diseases. Here, we investigated the prevalence and clinical impact of CH in patients with CTEPH.
View Article and Find Full Text PDFSocial Bonds Retain Oxytocin-Mediated Brain-Liver Axis to Retard Atherosclerosis.
Circ Res
November 2024
Department of Cardiology, Keio University School of Medicine, Tokyo, Japan. (S.K., A.A., X.L., G.I., H.K., K.S., Y.K., J.E., M.S., M.I.).
Article Synopsis
- * In an experiment, genetically similar mice on a high-fat diet were either isolated or housed together for 12 weeks to study the effects on heart health and metabolism, using various biological analyses to measure changes.
- * Findings revealed that socially isolated mice developed more severe atherosclerosis due to disrupted lipid metabolism and reduced oxytocin levels, suggesting that social connections enhance lipid management and overall cardiovascular health through a brain-liver communication pathway.
[Important role of relationship between brain and spleen in the mechanisms of chronic pain development and maintenance in fibromyalgia].
Nihon Yakurigaku Zasshi
November 2024
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University.
Article Synopsis
- * Researchers used a mouse model to study FM, discovering that injecting acid into muscle can induce pain sensitivity, influenced by splenocytes (immune cells from the spleen).
- * Their findings suggest that sympathetic nervous system activity and immune responses in the spleen are critical in developing and maintaining chronic pain, particularly under physical or psychological stress.
Paraneoplastic neurological syndrome and its impact on the treatment outcomes of small-cell lung cancer: A single-center retrospective analysis.
Thorac Cancer
December 2024
Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
Introduction: Paraneoplastic neurological syndrome (PNS) is associated with small-cell lung cancer (SCLC). However, the frequency and characteristics of PNS and the efficacy of anticancer treatment for these patients have not been investigated in the Japanese/Asian population previously. Therefore, we aimed to better understand PNS by evaluating real-world data from patients with PNS complicated by SCLC.
View Article and Find Full Text PDFVagal sensory neuron-derived FGF3 controls insulin secretion.
Dev Cell
October 2024
Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 01595, USA; Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA. Electronic address:
Vagal nerve stimulation has emerged as a promising modality for treating a wide range of chronic conditions, including metabolic disorders. However, the cellular and molecular pathways driving these clinical benefits remain largely obscure. Here, we demonstrate that fibroblast growth factor 3 (Fgf3) mRNA is upregulated in the mouse vagal ganglia under acute metabolic stress.
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