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Ligelizumab improves sleep interference and disease burden in patients with chronic spontaneous urticaria.
Clin Transl Allergy
February 2022
Novartis Pharma AG, Basel, Switzerland.
Background: Chronic spontaneous urticaria (CSU) negatively impacts patients' sleep, thereby reducing health-related quality of life (HRQoL). Half of patients with inadequately controlled CSU report sleep interference often or every night, which can lead to depression, anxiety, social, and work-related problems.
Methods: This randomized, double-blind, placebo-controlled Phase 2b core study (NCT02477332) included adult patients ≥18 years with moderate to severe CSU inadequately controlled with H -antihistamines.
Chronic urticaria patients are interested in apps to monitor their disease activity and control: A UCARE CURICT analysis.
Clin Transl Allergy
December 2021
Institute for Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Article Synopsis
- Chronic urticaria (CU) patients show a significant interest in using mobile apps to monitor their disease activity and control, with over half expressing high levels of interest in app usage.
- A study involving 1841 CU patients from 17 countries found that a majority have chronic spontaneous urticaria (CSU) and are predominantly female and urban-dwelling.
- The findings suggest that the development of tailored and expert-validated apps for different urticaria types could enhance disease management and inform future research efforts.
Chronische spontane Urtikaria in Verbindung mit einer primär billiären Cholangitis: ein Fallbericht und Literaturüberblick.
J Dtsch Dermatol Ges
November 2016
Department of Dermatology and Venereology, Sechenov First Moscow State Medical University, Moskau, Russland.
[Chronic spontaneous urticaria: An autoimmune disease?].
Hautarzt
September 2013
Klinik für Dermatologie, Venerologie und Allergologie, Allergie-Centrum-Charité, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.
The identification of the causes of chronic spontaneous urticaria (CSU) is difficult. The recognition of functional autoantibodies against FcεRI and/or against IgE in some patients with CSU led to the concept of autoimmune etiology of the disease. Clinical and laboratory features in a subpopulation of CSU patients also point to an autoimmune etiology of the disease.
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