Structure Elucidation of Antibiotics by Nmr Spectroscopy.

Methods Mol Biol

Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University, Universitaetsstrasse 1, 40225, Duesseldorf, Germany.

Published: January 2018

AI Article Synopsis

  • Nuclear magnetic resonance (NMR) spectroscopy is an important technique for determining the structures of antibiotics in solution.
  • Over the last 30 years, many studies have utilized NMR to analyze both natural and synthetic antibiotics.
  • This chapter will focus on essential 1D and 2D NMR experiments that help in understanding the structure of these compounds.

Article Abstract

Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool for the structure elucidation of antibiotics in solution. Over the past 30 years there have been numerous publications describing the use of NMR to characterize naturally derived or synthetic antibiotics. A large number of one-dimensional (1D) and two-dimensional (2D) NMR methods are available today and the list continues to expand. In this chapter, we will consider the key NMR experiments that provide useful information for compound structure elucidation.

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http://dx.doi.org/10.1007/978-1-4939-6634-9_4DOI Listing

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