Two blinded single-dose studies randomized children 6 months to 11 years old with fever to receive ibuprofen (IBU) pediatric suspension 7.5 mg/kg or acetaminophen (APAP) suspension 10 to 15 mg/kg. The primary efficacy parameter was time-weighted sum of temperature differences (TWSTD) from baseline through 8 hours for each study. Secondary end points included TWSTD from baseline through 6 hours, time to onset and duration of temperature control, and proportion with temperature control. Studies were pooled for post hoc analyses of efficacy and adverse event end points. The primary efficacy parameter significantly favored IBU over APAP in study 1 and the pooled analysis (both P < .001), but was not significant in study 2. Onset of temperature control significantly favored IBU in study 2 ( P = .007). Individual and pooled secondary efficacy outcomes supported significant advantages ( P < .05) of IBU over APAP. IBU pediatric suspension provided greater temperature reduction versus acetaminophen in febrile children, with a comparable safety profile.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/0009922816678818 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enhanced Light-Matter Interaction with Bloch Surface Wave Modulated Plasmonic Nanocavities.
Nano Lett
January 2025
State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics, School of Physics, Peking University, 100871 Beijing, China.
Strong coupling between nanocavities and single excitons at room temperature is important for studying cavity quantum electrodynamics. However, the coupling strength is highly dependent on the spatial light-confinement ability of the cavity, the number of involved excitons, and the orientation of the electric field within the cavity. By constructing a hybrid cavity with a one-dimensional photonic crystal cavity and a plasmonic nanocavity, we effectively improve the quality factor, reduce the mode volume, and control the direction of the electric field using Bloch surface waves.
View Article and Find Full Text PDFDecoding Plant-Based Green Synthesis of Zinc Oxide Nanoparticles.
Chem Biodivers
January 2025
Physics Department, Centre National de la Recherche Scientifique (Unité Mixte de Recherche 6283), Institut des Molécules et Matériaux du Mans, Le Mans Université, Le Mans, France.
This study presents, for the first time, the comparison of behavior between two commonly found plant species, their extracts, and their major constituents (glucose and sucrose constituting over 70% of their dried extract) to synthesize zinc oxide (ZnO) nanoparticles (NPs) from zinc nitrate hexahydrate. The findings underscore the critical role of sugars as key constituents in facilitating this synthesis. This research demonstrates that the process can occur at relatively low temperatures (120°C).
View Article and Find Full Text PDFPrecise Preparation of Size-Uniform Two-Dimensional Platelet Micelles Through Crystallization-Assisted Rapid Microphase Separation Using All-Bottlebrush-Type Block Copolymers with Crystalline Side Chains.
J Am Chem Soc
January 2025
Tianjin Key Laboratory of Brine Chemical Engineering and Resource Eco-utilization, College of Chemical Engineering and Materials Science, Tianjin University of Science & Technology, Tianjin 300457, P. R. China.
Polymer nanoparticles with low curvature, especially two-dimensional (2D) soft materials, are rich in functions and outstanding properties and have received extensive attention. Crystallization-driven self-assembly (CDSA) of linear semicrystalline block copolymers is currently a common method of constructing 2D platelets of uniform size. Although accompanied by high controllability, this CDSA method usually and inevitably requires a longer aging time and lower assembly concentration, limiting the large-scale preparation of nanoaggregates.
View Article and Find Full Text PDFAssessing the efficacy of synthetic compounds foliar sprays in alleviating terminal heat stress in late-sown wheat ().
Funct Plant Biol
January 2025
Krishi Vigyan Kendra, Siwan, Dr. RPCAU, Pusa, Bihar, India.
Detrimental effects of terminal heat stress could be mitigated by exogenous application of synthetic compounds by preserving cell membrane integrity and protecting against oxidative damage. A field experiment was conducted to test the application of seven synthetic compounds on wheat growth traits: (1) thiourea (20 mM and 40mM); (2) potassium nitrate (1% and 2%); (3) sodium nitroprusside (400 μg mL-1 and 800μg mL-1 ); (4) dithiothreitol (25 ppm and 50ppm); (5) salicylic acid (100 ppm and 200ppm); (6) thioglycolic acid (200 ppm and 500ppm); and (7) putrescine (4 mM and 6mM). These compounds were applied at the anthesis and grain-filling stages to enhance physio-biochemical traits and yield attributes of wheat (Triticum aestivum ) cvs GW-11 and GW-496 under terminal heat stress.
View Article and Find Full Text PDFThermogelation of nanoemulsions stabilized by a commercial pea protein isolate: high-pressure homogenization defines gel strength.
Soft Matter
January 2025
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
The impact of animal-based food production on climate change drives the development of plant-based alternatives. We demonstrate the use of colloidal thermogelation on a real nanoemulsion system to create structured gels that could be of interest for thermo-mechanical processing of next-generation plant-based food applications. We use a commercial pea protein isolate (PPI) without further purification to stabilize a 20 vol% peanut oil-in-water nanoemulsion at pH = 7 by high-pressure homogenization (HPH) and demonstrate the temperature induced gelation behavior of the nanoemulsion as a function of the HPH processing parameters.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!