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<PubmedArticle><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27870550</PMID><DateCompleted><Year>2017</Year><Month>06</Month><Day>12</Day></DateCompleted><DateRevised><Year>2018</Year><Month>05</Month><Day>10</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1945-7197</ISSN><JournalIssue CitedMedium="Internet"><Volume>102</Volume><Issue>2</Issue><PubDate><Year>2017</Year><Month>Feb</Month><Day>01</Day></PubDate></JournalIssue><Title>The Journal of clinical endocrinology and metabolism</Title><ISOAbbreviation>J Clin Endocrinol Metab</ISOAbbreviation></Journal><ArticleTitle>Clinical and Immunological Characteristics of Autoimmune Addison Disease: A Nationwide Swedish Multicenter Study.</ArticleTitle><Pagination><StartPage>379</StartPage><EndPage>389</EndPage><MedlinePgn>379-389</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1210/jc.2016-2522</ELocationID><Abstract><AbstractText Label="CONTEXT">Studies of the clinical and immunological features of autoimmune Addison disease (AAD) are needed to understand the disease burden and increased mortality.</AbstractText><AbstractText Label="OBJECTIVE">To provide upgraded data on autoimmune comorbidities, replacement therapy, autoantibody profiles, and cardiovascular risk factors.</AbstractText><AbstractText Label="DESIGN, SETTING, AND PARTICIPANTS">A cross-sectional, population-based study that included 660 AAD patients from the Swedish Addison Registry (2008-2014). When analyzing the cardiovascular risk factors, 3594 individuals from the population-based survey in Northern Sweden, MONICA (monitoring of trends and determinants of cardiovascular disease), served as controls.</AbstractText><AbstractText Label="MAIN OUTCOME MEASURES">The endpoints were the prevalence of autoimmune comorbidities and cardiovascular risk factors. Autoantibodies against 13 autoantigens were determined.</AbstractText><AbstractText Label="RESULTS">The proportion of 21-hydroxylase autoantibody-positive patients was 83%, and 62% of patients had &#x2265;1 associated autoimmune diseases, more frequently coexisting in females (P &lt; 0.0001). AAD patients had a lower body mass index (P &lt; 0.0001) and prevalence of hypertension (P = 0.027) compared with controls. Conventional hydrocortisone tablets were used by 89% of the patients, with a mean dose of 28.1 &#xb1; 8.5 mg/d. The mean hydrocortisone equivalent dose normalized to the body surface was 14.8 &#xb1; 4.4 mg/m2/d. A greater hydrocortisone equivalent dose was associated with a greater incidence of hypertension (P = 0.046).</AbstractText><AbstractText Label="CONCLUSIONS">Careful monitoring of AAD patients is warranted to detect associated autoimmune diseases. Contemporary Swedish AAD patients did not have an increased prevalence of overweight, hypertension, type 2 diabetes mellitus, or hyperlipidemia. However, high glucocorticoid replacement doses could be a risk factor for hypertension.</AbstractText><CopyrightInformation>Copyright &#xa9; 2017 by the Endocrine Society</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dalin</LastName><ForeName>Frida</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Centre for Molecular Medicine, Department of Medicine (Solna).</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Science for Life Laboratory, Department of Medical Sciences, and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nordling Eriksson</LastName><ForeName>Gabriel</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine and Surgery, and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dahlqvist</LastName><ForeName>Per</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Public Health and Clinical Medicine and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hallgren</LastName><ForeName>&#xc5;sa</ForeName><Initials>&#xc5;</Initials><AffiliationInfo><Affiliation>Centre for Molecular Medicine, Department of Medicine (Solna).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wahlberg</LastName><ForeName>Jeanette</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of Endocrinology, Department of Medical and Health Sciences, Faculty of Health Sciences, and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ekwall</LastName><ForeName>Olov</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Institute of Clinical Sciences.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>S&#xf6;derberg</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Public Health and Clinical Medicine and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>R&#xf6;nnelid</LastName><ForeName>Johan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Departments of Immunology, Genetics and Pathology.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olc&#xe9;n</LastName><ForeName>Per</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Laboratory Medicine and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Winqvist</LastName><ForeName>Ola</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Translational Immunology, Department of Medicine (Solna), and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Catrina</LastName><ForeName>Sergiu-Bogdan</ForeName><Initials>SB</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine and Surgery, and.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Karolinska Institutet, Stockholm SE-17176, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kristr&#xf6;m</LastName><ForeName>Berit</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Institution of Clinical Science, Pediatrics, Ume&#xe5; University, Ume&#xe5; SE-90736, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laudius</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Public Health and Clinical Medicine and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Isaksson</LastName><ForeName>Magnus</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Medical Sciences, and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Halldin Stenlid</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Women's and Children's Health, Uppsala University, Uppsala SE-75236, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gustafsson</LastName><ForeName>Jan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Women's and Children's Health, Uppsala University, Uppsala SE-75236, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gebre-Medhin</LastName><ForeName>Gennet</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Women's and Children's Health, Uppsala University, Uppsala SE-75236, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bj&#xf6;rnsdottir</LastName><ForeName>Sigridur</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine and Surgery, and.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Karolinska Institutet, Stockholm SE-17176, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Janson</LastName><ForeName>Annika</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Women's and Children's Health, Karolinska Institutet, Stockholm SE-17176, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>&#xc5;kerman</LastName><ForeName>Anna-Karin</ForeName><Initials>AK</Initials><AffiliationInfo><Affiliation>Department of Laboratory Medicine and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>&#xc5;man</LastName><ForeName>Jan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Faculty of Medicine and Health, &#xd6;rebro University, &#xd6;rebro SE-70281, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duchen</LastName><ForeName>Karel</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Division of Pediatrics, Department of Clinical and Experimental Medicine, Link&#xf6;ping University, Link&#xf6;ping SE-58183, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bergthorsdottir</LastName><ForeName>Ragnhildur</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, and.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Endocrinology, Sahlgrenska University Hospital, Sahlgrenska Academy, University of Gothenburg, Gothenburg SE-40530, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johannsson</LastName><ForeName>Gudmundur</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, and.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Endocrinology, Sahlgrenska University Hospital, Sahlgrenska Academy, University of Gothenburg, Gothenburg SE-40530, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lindskog</LastName><ForeName>Emma</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Institute of Clinical Sciences.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Landin-Olsson</LastName><ForeName>Mona</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Sk&#xe5;ne University Hospital, Lund SE-22362, Sweden; and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Elfving</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Pediatric Endocrinology, Clinical Sciences, Lund University, Lund SE-22362, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Waldenstr&#xf6;m</LastName><ForeName>Erik</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Sk&#xe5;ne University Hospital, Lund SE-22362, Sweden; and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hulting</LastName><ForeName>Anna-Lena</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine and Surgery, and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>K&#xe4;mpe</LastName><ForeName>Olle</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Centre for Molecular Medicine, Department of Medicine (Solna).</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Karolinska Institutet, Stockholm SE-17176, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bensing</LastName><ForeName>Sophie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine and Surgery, and.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Karolinska Institutet, Stockholm SE-17176, Sweden.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Clin Endocrinol Metab</MedlineTA><NlmUniqueID>0375362</NlmUniqueID><ISSNLinking>0021-972X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001323">Autoantibodies</NameOfSubstance></Chemical><Chemical><RegistryNumber>WI4X0X7BPJ</RegistryNumber><NameOfSubstance UI="D006854">Hydrocortisone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000224" MajorTopicYN="N">Addison Disease</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001323" MajorTopicYN="N">Autoantibodies</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001327" MajorTopicYN="N">Autoimmune Diseases</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002318" MajorTopicYN="N">Cardiovascular Diseases</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004334" MajorTopicYN="N">Drug Administration Schedule</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020249" MajorTopicYN="N">Hormone Replacement Therapy</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006854" MajorTopicYN="N">Hydrocortisone</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration &amp; dosage</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012042" MajorTopicYN="N">Registries</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013548" MajorTopicYN="N">Sweden</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>6</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>10</Month><Day>7</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>11</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>6</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>11</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27870550</ArticleId><ArticleId IdType="doi">10.1210/jc.2016-2522</ArticleId></ArticleIdList></PubmedData></PubmedArticle></PubmedArticleSet>