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| http://dx.doi.org/10.21037/sci.2016.10.04 | DOI Listing |
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circRNA_8521 promotes Senecavirus A infection by sponging miRNA-324 to regulate LC3A.
Vet Res
April 2024
Southwest University, College of Veterinary Medicine, Chongqing, 400715, China.
Senecavirus A (SVA) causes outbreaks of vesicular disease in pigs, which imposes a considerable economic burden on the pork industry. As current SVA prevention measures are ineffective, new strategies for controlling SVA are urgently needed. Circular (circ)RNA is a newly characterized class of widely expressed, endogenous regulatory RNAs, which have been implicated in viral infection; however, whether circRNAs regulate SVA infection remains unknown.
View Article and Find Full Text PDFmiRNA Expression Patterns in Early- and Late-Stage Prostate Cancer Patients: High-Throughput Analysis.
Biomedicines
November 2023
Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, Institute of Biochemistry and Genetics, 450054 Ufa, Russia.
Prostate cancer (PCa) is one of the most common types of cancer among men. To date, there have been no specific markers identified for the diagnosis and prognosis or response to treatment of this disease. Thus, there is an urgent need for promising markers, which may be fulfilled by small non-coding RNAs known as microRNAs (miRNAs).
View Article and Find Full Text PDFAge-Dependent Regulation of Dendritic Spine Density and Protein Expression in Mir324 KO Mice.
J Mol Neurosci
October 2023
University of Cincinnati Neuroscience Graduate Program, Cincinnati, OH, 45229, USA.
Dendritic spines are small, dynamic protrusions along the dendrite that comprise more than 90% of excitatory connections in the brain, making them essential sites for neuronal communication. These synaptic sites change throughout the process of development, reducing in density and shifting morphology as synapses are refined. One important class of dendritic spine regulators is microRNA (miRNA), small-noncoding RNAs that post-transcriptionally regulate gene expression.
View Article and Find Full Text PDFDendritic spines are small, dynamic protrusions along the dendrite that comprise more than 90% of excitatory connections in the brain, making them essential sites for neuronal communication. These synaptic sites change throughout the process of development, reducing in density and shifting morphology as synapses are refined. One important class of dendritic spine regulators is microRNA (miRNA), small noncoding RNAs that post-transcriptionally regulate gene expression.
View Article and Find Full Text PDFA review on the role of miRNA-324 in various diseases.
Front Genet
August 2022
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Recent studies have revealed important functions of several microRNAs (miRNAs) in the pathogenesis of human diseases. miR-324 is an example of miRNAs with crucial impacts on the pathogenesis of a wide range of disorders. Gene ontology studies have indicated possible role of miR-324 in responses of cells to the leukemia inhibitory factor, long-term synaptic potentiation, positive regulation of cytokines production and sensory perception of sound.
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