The aim of this study was to determine the uptake of intravenously administered N-[CH]-dimethylaminoparthenolide (DMAPT) into orthotopic 9LSF glioblastoma brain tumors in Fisher 344 rats from positron emission tomography (PET) imaging studies. [C]methyl iodide (CHI) was utilized as a [C]-labeling reagent to label the precursor methylaminoparthenolide (MAPT) intermediate. From PET imaging studies it was found that brain uptake of N-[CH]DMAPT into brain tumor tissue was rapid (30min), and considerably higher than that in the normal brain tissue.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154296 | PMC |
| http://dx.doi.org/10.1016/j.bmcl.2016.11.015 | DOI Listing |
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