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Intracellular synthesis of gold nanoparticles with antioxidant activity by probiotic Lactobacillus kimchicus DCY51 isolated from Korean kimchi. | LitMetric

Intracellular synthesis of gold nanoparticles with antioxidant activity by probiotic Lactobacillus kimchicus DCY51 isolated from Korean kimchi.

Enzyme Microb Technol

Graduate School of Biotechnology, College of Life Science, Kyung Hee University, Republic of Korea; Department of Oriental Medicine Biotechnology and Ginseng Bank, College of Life Science, Kyung Hee University, Republic of Korea. Electronic address:

Published: December 2016

AI Article Synopsis

  • Gold nanoparticles (AuNps) were successfully synthesized using the probiotic Lactobacillus kimchicus DCY51 from kimchi through a bioreduction method.
  • The AuNps produced were spherical, sized between 5-30nm, with an average crystallite size of 13nm, and showed long-term stability in various media.
  • These nanoparticles are non-toxic to certain human cell lines and have superior antioxidant properties, suggesting their potential use in drug delivery, cancer diagnosis, and medical imaging applications.

Article Abstract

A straightforward synthesis of gold nanoparticles (AuNps) is achieved by novel probiotic Lactobacillus kimchicus DCY51 isolated from Korean kimchi via an intracellular membrane-bound mechanism. The bioreduction of HAuCl into AuNps was verified by ultraviolet-visible spectrophotometry at ∼540nm. AuNps were spherical with varying sizes of 5-30nm. AuNps maintained an average crystallite size of 13nm and demonstrated long-term stability in physiological buffer and biological media. Furthermore, the protective capping layer consisted of amino acid residues and surface-bound proteins rendered them non-toxic to murine macrophage (RAW264.7) and human colorectal adenocarcinoma (HT29) cell lines. Finally, biosynthesized AuNps served as superior free radical scavengers against 2,2-diphenyl-1-picrylhydrazyl (DPPH) in contrast to their corresponding gold salt. In short, this green synthesis is cost-effective and advantageous for the development of a new class of probiotics mediated and non-toxic carriers in targeted drug delivery systems, cancer diagnostic, photothermal therapy, biosensing, and medical imaging.

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Source
http://dx.doi.org/10.1016/j.enzmictec.2016.08.018DOI Listing

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