Biosynthesis of gold nanoparticles (AuNPs) using Sargassum swartzii and its anti-diabetic effect were studied using male wistar Albino rats. Formation of AuNPs were confirmed by UV-vis spectroscopy, Fourier transformed infrared (FTIR) spectroscopy, High-Resolution transmission electron microscopy (HR-TEM) and X-ray diffraction (XRD). Fasting blood glucose levels, serum insulin, hemoglobin and glycosylated hemoglobin levels in diabetic treated rats with AuNPs were significantly decreased compared to the control group. The results of the blood glucose level and serum insulin levels indicated that AuNPs could significantly improve the insulin resistance and glucose level in diabetic rats. AuNPs also shows reduction in anti-inflammation, tumor necrosis factor-alpha, interleukin-6 and high-sensitive C-reactive protein in diabetic rats. The data showed that AuNPs synthesized using S. swartzii exerted antidiabetic effect, accordingly improve pancreas, liver and kidney damage caused by alloxan induced diabetic rats.
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