A Case of Nivolumab-Induced Myositis.

Oncologist

Paoli Hospital Cancer Center, Paoli, Pennsylvania, USA.

Published: December 2016

AI Article Synopsis

Article Abstract

Nivolumab (Opdivo) is a monoclonal antibody classified as an immune modulator. A case is presented of nivolumab-induced myositis, an unlisted side effect.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153342PMC
http://dx.doi.org/10.1634/theoncologist.2016-0170DOI Listing

Publication Analysis

Top Keywords

nivolumab-induced myositis
8
case nivolumab-induced
4
myositis nivolumab
4
nivolumab opdivo
4
opdivo monoclonal
4
monoclonal antibody
4
antibody classified
4
classified immune
4
immune modulator
4
modulator case
4

Similar Publications

Nivolumab blocks inhibitors of T-cell activation and restores antitumor immunity but promotes T-cell activity in host tissues by blocking inhibition of the T-cell function, resulting in immune-related adverse effects. We herein report an 80-year-old man presenting with nivolumab-related myasthenia gravis with anti-muscular voltage-gated potassium channel-complex (Kv1.4) antibodies.

View Article and Find Full Text PDF

Clinical characteristics, treatment and outcome of nivolumab-induced myasthenia gravis.

Invest New Drugs

April 2023

Department of Pharmacy, The Third Xiangya Hospital, Central South University, No. 138 Tongzipo Road, YueLu District, 410013, Changsha, Hunan, China.

Background: To investigate the clinical features of nivolumab-induced myasthenia gravis (MG) and provide evidence for the rational use of nivolumab in the clinic.

Methods: We collected case reports and case series of nivolumab-induced MG for retrospective analysis by searching Chinese and English databases from 2014 to October 31, 2022.

Results: Of the 67 patients included, the median age was 72.

View Article and Find Full Text PDF

Nivolumab-induced Diaphragm Dysfunction: A Case Report.

Indian J Crit Care Med

February 2023

Department of Intensive Care Medicine, Amsterdam University Medical Centers, Amsterdam, North Holland, Netherlands.

Unlabelled: Nivolumab is increasingly used in the treatment of melanoma. However, its use is associated with potentially severe side effects and every organ system can be affected. A case is presented where nivolumab therapy resulted in severe diaphragm dysfunction.

View Article and Find Full Text PDF

Nivolumab (NIVO) is a monoclonal antibody used to treat renal cell cancer. It is an anti-programmed death-1 (anti-PD-1) inhibitor, enhancing the tumor-targeted immune response of T lymphocytes, resulting in immune-mediated adverse events (AEs). We present five immunological AEs in a single patient treated with NIVO.

View Article and Find Full Text PDF

Immune checkpoint inhibitors (ICIs) are complicated by immune-related adverse events (irAEs), such as myositis, myocarditis, and myasthenia gravis (MG). Anti-titin antibody and anti-voltage-gated potassium channel Kv1.4 antibody are anti-striated antibodies that are frequently detected in MG patients with myositis and/or myocarditis.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!