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Pooled PPIseq: Screening the SARS-CoV-2 and human interface with a scalable multiplexed protein-protein interaction assay platform.
PLoS One
January 2025
SLAC National Accelerator Laboratory, Stanford University, Stanford, California, United States of America.
Protein-Protein Interactions (PPIs) are a key interface between virus and host, and these interactions are important to both viral reprogramming of the host and to host restriction of viral infection. In particular, viral-host PPI networks can be used to further our understanding of the molecular mechanisms of tissue specificity, host range, and virulence. At higher scales, viral-host PPI screening could also be used to screen for small-molecule antivirals that interfere with essential viral-host interactions, or to explore how the PPI networks between interacting viral and host genomes co-evolve.
View Article and Find Full Text PDFLeucine-rich alpha-2 glycoprotein in combination with C-reactive protein for predicting endoscopic activity in Crohn's disease: a single-centre, cross-sectional study.
Ann Med
December 2025
Department of Internal Medicine, Division of Gastroenterology and Hepatology, Keio University School of Medicine, Tokyo, Japan.
Background And Objective: Leucine-rich alpha-2 glycoprotein (LRG) is a novel biomarker for Crohn's disease (CD). The utility of combination use of LRG and C-reactive protein (CRP) has not been reported. This study aimed to investigate the diagnostic performance of LRG in combination with CRP to predict endoscopic activity.
View Article and Find Full Text PDFSTRAIGHTMORPH: A Voice Morphing Tool for Research in Voice Communication Sciences.
Open Res Eur
January 2025
Center for Innovative Research and Liaison, Wakayama University, Wakayama, Wakayama Prefecture, Japan.
The purpose of this paper is to make easily available to the scientific community an efficient voice morphing tool called STRAIGHTMORPH and provide a short tutorial on its use with examples. STRAIGHTMORPH consists of a set of Matlab functions allowing the generation of high-quality, parametrically-controlled morphs of an arbitrary number of voice samples. A first step consists in extracting an 'mObject' for each voice sample, with accurate tracking of the fundamental frequency contour and manual definition of Time and Frequency anchors corresponding across samples to be morphed.
View Article and Find Full Text PDFFreeze-Casting Mold-Based Scalable Synthesis of Directional Graphene Aerogels with Long-Range Pore Alignment for Energy Applications.
Small Methods
January 2025
School of Mechanical and Aerospace Engineering, Gyeongsang National University, Jinju, 52828, South Korea.
In various applications, the pore structure of a porous medium must be controlled to facilitate heat and mass transfer, which considerably influence the system performance. Freeze-casting is a versatile technique for creating aligned pores; However, because of the complexity of the associated equipment and the energy inefficiency of liquid-nitrogen-based cooling in a room-temperature environment, limits scalability for industrial applications. This study is aimed at establishing a novel freeze-casting strategy with a simple mold design combining heat-conductive and insulating materials for long-range pore alignment via directional ice growth under deep-freezing conditions, rendering it feasible for large-scale production.
View Article and Find Full Text PDFEpidemiological and genotypic assessment of cystic echinococcosis in ruminant populations of Northern Punjab, Pakistan: a neglected zoonotic disease.
Parasitol Res
January 2025
Department of Parasitology, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Echinococcus granulosus is a zoonotic dog parasite, which causes cystic echinococcosis in humans and animals, adversely affecting health and food production. The resultant socio-economic impacts in lower-middle-income countries and the paucity of epidemiology data prompted the World Health Organization to classify cystic echinococcosis as a neglected tropical disease. Between November 2019 and December 2020, the prevalence of cystic echinococcosis was assessed from 3600 post-slaughter livestock (1142 sheep, 1258 goats and 1200 buffalo) from three districts, Narowal, Sheikhupura and Sialkot, in Northern Punjab, Pakistan.
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