The application of menthol has recently been researched as a performance-enhancing aid for various aspects of athletic performance including endurance, speed, strength and joint range of motion. A range of application methods has been used including a mouth rinse, ingestion of a beverage containing menthol or external application to the skin or clothing via a gel or spray. The majority of research has focussed on the use of menthol to impart a cooling sensation on athletes performing endurance exercise in the heat. In this situation, menthol appears to have the greatest beneficial effect on performance when applied internally. In contrast, the majority of investigations into the external application of menthol demonstrated no performance benefit. While studies are limited in number, menthol has not yet proven to be beneficial for speed or strength, and only effective at increasing joint range of motion following exercise that induced delayed-onset muscle soreness. Internal application of menthol may provoke such performance-enhancing effects via mechanisms related to its thermal, ventilatory, analgesic and arousing properties. Future research should focus on well-trained subjects and investigate the addition of menthol to nutritional sports products.
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Anal Chim Acta
February 2025
Departamento de Medio Ambiente y Agronomía, INIA-CSIC, Carretera de A Coruña km. 7.5, 28040, Madrid, Spain. Electronic address:
Background: At present, 3D printing technology is becoming increasingly popular in analytical chemistry because it enables the rapid and cost-effective manufacture of sample preparation devices, particularly in flow-based operation, opening up new opportunities for the development of automated analytical methods. In parallel, the use of miniaturized methods and sustainable solvents in sample preparation is highly recommended. Accordingly, in this work, a 3D-printed millifluidic device was designed and used for the on-line natural deep eutectic solvent (NADES)-based liquid phase microextraction (LPME) coupled to a spectrofluorometer for, as a proof of concept, the determination of thiabendazole (TBZ) in fruit juice samples.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Department of Chemical Engineering and Environmental Technology, Universidad de Zaragoza, Campus Río Ebro-Edificio I+D, 50018 Zaragoza, Spain.
The emergence of green chemistry and engineering principles to enforce sustainability aspects has ensured the prevalence of green solvents and green processes. Our study addresses this quest by exploring drug delivery applications of hydrophobic deep eutectic solvents (DESs) which are alternative green solvents. Initially, this work showcases the hydrophobic drug solubilization capabilities of a natural hydrophobic DES, menthol, and decanoic acid.
View Article and Find Full Text PDFPlants (Basel)
December 2024
Academic Clinical Center of Trás-os-Montes and Alto Douro (CACTMAD), University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal.
Chronic pruritus, or persistent itching, is a debilitating condition that severely impacts quality of life, especially in palliative care settings. Traditional treatments often fail to provide adequate relief or are associated with significant side effects, prompting interest in alternative therapies. This review investigates the antipruritic potential of eight medicinal plants: chamomile (), aloe vera (), calendula (), curcumin (), lavender (), licorice (), peppermint (), and evening primrose ().
View Article and Find Full Text PDFNutrients
December 2024
Food Chemistry and Nutraceutical Laboratory, Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Background: Three herbal extracts ( Willd., Lorentz, and L.) were mixed with three essential oils ( Mill.
View Article and Find Full Text PDFInt J Mol Sci
November 2024
School of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China.
Sinomenine (SIN) is a drug for the treatment of rheumatoid arthritis, most of which is administered orally, but it is prone to adverse gastrointestinal effects. Gel can overcome the gastrointestinal adverse effects caused by oral administration. In this paper, a multiscale computational pharmaceutics strategy was developed to guide the systematic study of formulation factors of a SIN gel and, further, to guide the formulation design.
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