AI Article Synopsis
- The study investigated how varying doses of radiation affect two types of salivary gland adenoid cystic carcinoma cells (SACC-83 and SACC-LM).
- Different doses (0, 2, 4, 6, 8, 10 Gy) were administered, and outcomes like cell growth, death, and movement were assessed using multiple scientific methods.
- Results showed that SACC-LM cells were more affected by radiation than SACC-83 cells, with 6 Gy being the most impactful dose for SACC-83 cells in terms of survival, apoptosis, and migration.
Article Abstract
Purpose: To explore the effect of different doses of radiation on human salivary gland adenoid cystic carcinoma cells (SACC-83, SACC-LM).
Methods: Different doses of radiation (0, 2, 4, 6, 8, 10 Gy) were applied to SACC-83, SACC-LM cells and the cells were continued to culture for 48 h. CCK-8 test, flow cytometry(FCM) and cell scratch experiment were used to observe cell proliferation, apoptosis and cell migration. SPSS19.0 software package was used for data analysis.
Results: The effect of radiation on SACC-LM cells survival rate, cell apoptosis, heteroploid and cell migration ability were significantly greater than that on SACC-83 cells (P<0.05). In SACC-83 cells, compared with other doses of radiation, 6 Gy of irradiation was the most sensitive on cell survival rate, cell apoptosis, heteroploid and cell migration ability.
Conclusions: Radiation sensitivity of SACC-LM was greater than that of SACC-83 cells. With 6 Gy of radiation, changes of biology in SACC-83 cells most significant than other doses of radiation.
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