Grafting a robust organic shell around inorganic nanoparticles can optimize their colloidal features to dramatically improve their physicochemical properties. Here, we have developed a polymer coating procedure for providing colloidal stability to the nanoparticles and, more importantly, for applying a fast, facile fluorine-18 labeling of iron oxide nanoparticles (IONPs) for positron emission tomography (PET)/magnetic resonance (MR) dual-modality imaging. The structure of the amphiphilic polymer is based on a backbone of polyacrylic acid, conjugated with multiple oleylamines to form a comb-like branched structure. The dense polymer shell provides high colloidal stability to the IONPs against harsh conditions such as high temperature, low pH value, and high ion strength. By incorporating a 1,4,7-triazacyclononane (NOTA) chelator to the comb-like amphiphilic polymer for the chelation of aluminum fluoride ions, we applied a one-step radiolabeling approach for a fast, facile radiofluorination of magnetic nanoparticles. The new strategy can significantly reduce the procedure time and radiation exposure. The PET/MR dual modality imaging was successfully achieved in living subjects by using F labeled magnetic nanoparticles.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154751 | PMC |
| http://dx.doi.org/10.1039/c6nr07298d | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fast-Charging Lithium-Ion Batteries Enabled by Magnetically Aligned Electrodes.
ACS Nano
January 2025
Materials Science and Engineering Program and Walker Department of Mechanical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.
With the increasing popularity of electric transportation over the past several years, fast-charging lithium-ion batteries are highly demanded for shortening electric vehicles' charging time. Extensive efforts have been made on material development and electrode engineering; however, few of them are scalable and cost-effective enough to be potentially incorporated into the current battery production. Here, we propose a facile magnetic templating method for preparing LiFePO (LFP) cathodes with vertically aligned graphene sheets to realize fast-charging properties at a practical loading of 20 mg cm.
View Article and Find Full Text PDFHalide perovskites, a game changer for future medical imaging technology.
Biophys Rev (Melville)
March 2025
School of Physics, Australian Centre for Microscopy and Microanalysis, Sydney Nano Institute, The University of Sydney, Sydney, NSW 2006, Australia.
The accurate detection of x-rays enables broad applications in various fields, including medical radiography, safety and security screening, and nondestructive inspection. Medical imaging procedures require the x-ray detection devices operating with low doses and high efficiency to reduce radiation health risks, as well as expect the flexible or wearable ones that offer more comfortable and accurate diagnosis experiences. Recently, halide perovskites have shown promising potential in high-performance, cost-effective x-ray detection owing to their attractive features, such as strong x-ray absorption, high-mobility-lifetime product, tunable bandgap, fast response, as well as low-cost raw materials, facile processing, and excellent flexibility.
View Article and Find Full Text PDFOne-step in-situ growth of histidine-modified ZIF-90 on natural eggshell membrane for efficient extraction of p-nitrophenol and 3-methyl-4-nitrophenol in human urine and environmental water.
Talanta
January 2025
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. Electronic address:
Monitoring of p-nitrophenol (PNP) and 3-methyl-4-nitrophenol (PNMC) in human urine and environmental water is of great importance for human health assessment and environmental protection, as they are both urinary metabolites of some poisonous pesticides and priority environmental pollutants. However, efficient extraction of trace levels of PNP and PNMC from complex matrices remains challenging. This study presented the synthesis of histidine-modified ZIF-90 on natural eggshell membrane (ESM@His-ZIF-90) via a facile one-step in-situ growth strategy, and its application as an adsorbent for dispersive membrane extraction (DME) of PNP and PNMC in human urine and environmental water.
View Article and Find Full Text PDFGradient Design with Low-tortuosity Overcoming Kinetic Limitations in High-Loading Solid-State Cathodes.
Angew Chem Int Ed Engl
January 2025
UT Austin: The University of Texas at Austin, Materials Science and Engineering, 1 University Station C2200, 78712, Austin, UNITED STATES OF AMERICA.
The extensive commercialization of practical solid-state batteries (SSBs) necessitates the development of high-loading solid-state cathodes with fast charging capability. However, electrochemical kinetics are severely delayed in thick cathodes due to tortuous ion transport pathways and slow solid-solid ion diffusion, which limit the achievable capacity of SSBs at high current densities. In this work, we propose a conductivity gradient cathode with low-tortuosity to enable facile ion transport and counterbalance ion concentration gradient, thereby overcoming the kinetic limitations and achieving fast charging capabilities in thick cathodes.
View Article and Find Full Text PDFThe inverse electron demand diels-alder (IEDDA): A facile bioorthogonal click reaction for development of injectable polysaccharide-based hydrogels for biomedical applications.
Carbohydr Polym
March 2025
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources and International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing 210037, China. Electronic address:
The inverse electron demand Diels-Alder (IEDDA) cycloaddition between tetrazines and strained dienophiles is recognized as a fast and specific reaction. The integrating tetrazines and strained dienophiles onto the backbone of polysaccharides yield appropriate water-soluble precursors for IEDDA cycloaddition. Due to the high specificity of the IEDDA reaction and its outstanding cytocompatibility, a range of cargos (live cells, peptides and pharmaceuticals) can be effectively encapsulated in polysaccharide solutions throughout the hydrogel formation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!