Failure to protect and/or restart stalled replication forks contributes to genomic instability. Radiation-sensitive 51 (RAD51) recombinase defends stalled forks from nucleolytic attack, which otherwise can threaten their integrity. Recently, we have uncovered a novel and key function of Werner helicase interacting protein 1 (WRNIP1) as a fork-protective factor working in conjunction with RAD51 in response to replication stress.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068177 | PMC |
| http://dx.doi.org/10.1080/23723556.2016.1215777 | DOI Listing |
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