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Article Abstract
True lymphovascular invasion in most carcinomas adversely affects survival, but human models of lymphatic invasion are lacking. Herein is discussed one such model in which certain mechanistic aspects of lymphatic dissemination can be investigated easily in any laboratory. S100P expression is known to be significantly upregulated in the lymph node metastases of human pancreatic adenocarcinoma. Thus, an S100P overexpressing cell line (S5L) and a vector control (V3L) pancreatic cancer cell lines were used to develop a co-culture model with human dermal lymphatic endothelial cells. Adhesion, the effect of cancer cells on lymphatic permeability and trans-lymphatic endothelial migration could be reproducibly quantified in this model and parametric statistical analysis confirmed significant differences between the two cancer cell lines in these functional assays. This proof-of-principle study demonstrates that this simple model can be used to assess lymphatic invasion in a human cancer context in real-time in vitro.
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| http://dx.doi.org/10.1136/jclinpath-2016-204106 | DOI Listing |
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Article Synopsis
- - The study investigates how lymphovascular invasion (LVI) affects overall survival in gastric cancer patients at pN0 stage after they've undergone surgery to remove the tumor.
- - Out of 497 patients reviewed, 19.9% had LVI, which was linked to significantly poorer survival rates; further analysis identified LVI and the number of examined lymph nodes as independent predictors of survival.
- - The findings suggest that for better outcomes, it is crucial to dissect more than 15 lymph nodes during surgery for patients with pN0 stage gastric cancer, especially those with LVI.
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