Prevalence of Colistin Resistance Gene mcr-1 and Absence of mcr-2 in Escherichia coli Isolated from Healthy Food-Producing Animals in Japan.

Michiko Kawanishi Hitoshi Abo Manao Ozawa Mariko Uchiyama Takahiro Shirakawa Satowa Suzuki Ayaka Shima Akifumi Yamashita Tsuyoshi Sekizuka Kengo Kato Makoto Kuroda Ryoji Koike Mayumi Kijima

Antimicrob Agents Chemother

National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, Kokubunji, Japan.

Published: January 2017

Researchers examined over 9,300 strains of Escherichia coli from healthy animals as part of the Japanese Veterinary Antimicrobial Resistance Monitoring (JVARM) program.
The mcr-1 gene was found in 39 strains, with sources including cattle, swine, and broilers, but mcr-2 was not detected at all.
A further investigation using a sequence homology search against the GenEpid-J database also confirmed the absence of mcr-2.

We screened mcr-1 and mcr-2 genes in 9,306 Escherichia coli strains isolated from healthy animals in the Japanese Veterinary Antimicrobial Resistance Monitoring (JVARM) system. mcr-1 was detected in 39 strains (5, 20, and 14 strains isolated from cattle, swine, and broilers, respectively), whereas mcr-2 was not detected. mcr-2 was also not detected with the investigation sequence homology search against our curated GenEpid-J database.

Download full-text PDF	Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192110	PMC
http://dx.doi.org/10.1128/AAC.02057-16	DOI Listing

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