AI Article Synopsis
- The study focused on creating a new type of drug delivery system using pH-responsive micelles to enhance the effectiveness of chemotherapy in breast cancer treatment.
- Researchers successfully developed paclitaxel-loaded micelles that were tested on specific breast cancer cells and in tumor-bearing mice, showing promising results in inhibiting cancer cell growth and metastasis.
- The findings suggest that these pH-responsive micelles could be a valuable option for targeted drug delivery in the acidic environment of tumors, potentially improving treatment outcomes for metastatic breast cancer.
Article Abstract
Aim: Tumor metastasis is one of the leading causes of insufficient chemotherapy during cancer treatment. In this study, a poly(β-amino ester) derivate was developed to fabricate paclitaxel (PTX) entrapped pH-responsive copolymer micelles for inhibition of breast cancer metastasis.
Materials & Methods: PTX-loaded micelles were fabricated by thin film hydration method. The inhibition efficacy of the as-prepared micelles was evaluated on MDA-MB-231 cells and tumor bearing mice.
Results: PTX-loaded micelles were successfully prepared. Such micelles could promote drug uptake and MDA-MB-231 cell deaths, and suppress tumor metastasis.
Conclusion: The pH-responsive PTX-loaded micelles are promising candidates in developing stimuli triggered drug delivery systems in acidic tumor microenvironments with improved inhibitory effects on tumor metastasis.
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| http://dx.doi.org/10.2217/nnm-2016-0335 | DOI Listing |
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