AI Article Synopsis
- The study aimed to evaluate the outcomes of breast-conserving surgery (BCS) combined with intraoperative radiotherapy (IORT) and identify risk factors for complications in patients with early-stage breast cancer.
- A total of 113 patients were monitored over a median follow-up period of 40.3 months, revealing a low recurrence rate (0.9%) and some complications including 7.7% for wound issues and 1.7% for fat necrosis.
- The research concluded that IORT is a generally safe treatment option, although the size of the IORT applicator significantly correlated with higher complication rates.
Article Abstract
Objective: The aim of this study was to evaluate outcomes after breast-conserving surgery (BCS) and intraoperative radiotherapy (IORT), and to identify risk factors associated with complications.
Materials/methods: We evaluated patients with early-stage breast cancer treated from January 1, 2011 to January 31, 2014 with BCS and IORT at a single institution. The presence of breast cancer recurrences, complications, or fat necrosis were assessed at subsequent follow-up visits using physical examination and breast imaging.
Results: Overall, 113 patients, of whom three were undergoing bilateral treatments, were identified. The median length of time for IORT was 29 min and 36 s (range 15:50-59:00). Fifteen patients received additional external beam radiotherapy (EBRT), and the median follow-up was 40.3 months (range 1.6-58.3) for all patients. To date, one biopsy-proven ipsilateral recurrence has been noted (0.9%), for which the patient elected to undergo a mastectomy. Nine patients were found to have wound complications (7.7%) and two had fat necrosis (1.7%) on follow-up. Of all the evaluated risk factors, only applicator size (p < 0.01) had a statistically significant association with an increase in complications.
Conclusions: With a short follow-up, IORT appears to be a safe treatment modality for a select group of patients, leading to a reasonable increase in operating room time and complication rates following BCS. The utilization of larger applicators at the time of IORT was associated with an increase in wound complications and fat necrosis.
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| http://dx.doi.org/10.1245/s10434-016-5679-0 | DOI Listing |
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