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Diversity patterns and knowledge gaps of Atlantic Forest epiphyllous bryophytes: a highly neglected group.
Ann Bot
January 2025
Laboratório de Ecologia e Biogeografia de Plantas, Departamento de Biodiversidade, Setor Palotina, Universidade Federal do Paraná, Rua Pioneiro, 2153, Jardim Dallas, CEP 85950 000, Palotina, Paraná, Brazil.
Background: Epiphyllous bryophytes are a group of plants with complex adaptations to colonize the leaves of vascular plants and are considered one of the most specialized and sensitive groups to environmental changes. Despite their specificity and ecological importance, these plants represent a largely neglected group in relation to scientific research and ecological data. This lack of information directly affects our understanding of biodiversity patterns and compromises the conservation of this group in threatened ecosystems.
View Article and Find Full Text PDFExamining Electronic Nicotine Delivery System (ENDS) Cue Reactivity Using a Remote Platform: Cigarette and ENDS Desire in Dual Users.
Nicotine Tob Res
January 2025
University of Chicago, Department of Psychiatry and Behavioral Neuroscience, Chicago, IL.
Introduction: Prior research shows that in-person exposure to electronic nicotine delivery systems (ENDS) use increases desire for cigarettes and ENDS. However, less is known about the impact of cues delivered during remote interactions. This study extends previous in-person cue work by leveraging a remote confederate-delivered cue-delivery paradigm to evaluate the impact of dual nicotine vaping (vs.
View Article and Find Full Text PDFCurrent and Emerging Therapies for Lysosomal Storage Disorders.
Drugs
January 2025
Lysosomal Storage Disorders Unit, Royal Free London NHS Foundation Trust, University College London, London, NW3 2QG, UK.
Lysosomal storage disorders (LSDs) are rare inherited metabolic disorders characterized by defects in the function of specific enzymes responsible for breaking down substrates within cellular organelles (lysosomes) essential for the processing of macromolecules. Undigested substrate accumulates within lysosomes, leading to cellular dysfunction, tissue damage, and clinical manifestations. Clinical features vary depending on the degree and type of enzyme deficiency, the type and extent of substrate accumulated, and the tissues affected.
View Article and Find Full Text PDFState-of-the-Art Liver Cancer Organoids: Modeling Cancer Stem Cell Heterogeneity for Personalized Treatment.
BioDrugs
January 2025
Orsay-Vallée Campus, Paris-Saclay University, Gif-sur-Yvette, France.
Liver cancer poses a global health challenge with limited therapeutic options. Notably, the limited success of current therapies in patients with primary liver cancers (PLCs) may be attributed to the high heterogeneity of both hepatocellular carcinoma (HCCs) and intrahepatic cholangiocarcinoma (iCCAs). This heterogeneity evolves over time as tumor-initiating stem cells, or cancer stem cells (CSCs), undergo (epi)genetic alterations or encounter microenvironmental changes within the tumor microenvironment.
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