Objectives: We investigated the potential of textural feature analysis of O-(2-[F]fluoroethyl)-L-tyrosine (F-FET) PET to differentiate radiation injury from brain metastasis recurrence.
Methods: Forty-seven patients with contrast-enhancing brain lesions (n = 54) on MRI after radiotherapy of brain metastases underwent dynamic F-FET PET. Tumour-to-brain ratios (TBRs) of F-FET uptake and 62 textural parameters were determined on summed images 20-40 min post-injection. Tracer uptake kinetics, i.e., time-to-peak (TTP) and patterns of time-activity curves (TAC) were evaluated on dynamic PET data from 0-50 min post-injection. Diagnostic accuracy of investigated parameters and combinations thereof to discriminate between brain metastasis recurrence and radiation injury was compared.
Results: Diagnostic accuracy increased from 81 % for TBR alone to 85 % when combined with the textural parameter Coarseness or Short-zone emphasis. The accuracy of TBR alone was 83 % and increased to 85 % after combination with the textural parameters Coarseness, Short-zone emphasis, or Correlation. Analysis of TACs resulted in an accuracy of 70 % for kinetic pattern alone and increased to 83 % when combined with TBR.
Conclusions: Textural feature analysis in combination with TBRs may have the potential to increase diagnostic accuracy for discrimination between brain metastasis recurrence and radiation injury, without the need for dynamic F-FET PET scans.
Key Points: • Textural feature analysis provides quantitative information about tumour heterogeneity • Textural features help improve discrimination between brain metastasis recurrence and radiation injury • Textural features might be helpful to further understand tumour heterogeneity • Analysis does not require a more time consuming dynamic PET acquisition.
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http://dx.doi.org/10.1007/s00330-016-4638-2 | DOI Listing |
Int J Surg
December 2024
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
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Department of Emergency Medicine, Chi Mei Medical Center, Tainan, Taiwan.
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Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100029, China.
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The mediastinal vasculature can be affected by various etiologies in cancer patients. Both direct and indirect sequela of cancer may result in life-threatening clinical presentations. Tumor growth may cause vessel narrowing and decreased blood flow from either extrinsic mass effect, invasion into the vascular wall, or tumor thrombus within the lumen.
View Article and Find Full Text PDFCell Transplant
January 2025
School of Basic Medicine Sciences, Shandong Second Medical University, Weifang, China.
Tissue repair is an extremely crucial part of clinical treatment. During the course of disease treatment, surgery, chemotherapy, and radiotherapy cause tissue damage. On the other hand, Normal tissue from accidental or therapeutic exposure to high-dose radiation can cause severe tissue damage.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!