A diastereoselective, gold-catalyzed cascading cycloisomerization of alkylidene cyclopropane bearing 1,5-enynes that terminates in a cyclo-addition of aldehydes has been developed. This diastereoselective reaction provides convergent access to novel polycyclic molecular structures (18 examples), and tolerates a diverse scope of aldehydes. Mechanistic studies reveal that the catalytic cycle rests at a digold off-cycle intermediate, one of which was isolated.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134929 | PMC |
http://dx.doi.org/10.1039/c6ob02128j | DOI Listing |
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