We herein report the case of a 63-year-old man who presented with a 3-month history of a cutaneous nodular lesion of his jaw, low grade fever, lethargy and progressive cognitive impairment. He had a 30-year history of multiple sclerosis and had been treated with fingolimod for the previous 2 years. Laboratory data revealed CD4 lymphocytopenia and a tissue culture of the skin nodule was positive for Cryptococcus neoformans. Cerebrospinal fluid and serum cryptococcal antigen tests were also positive and we diagnosed him to have disseminated cryptococcosis. This dissemination might be associated with fingolimod-induced CD4 lymphocytopenia. The risk of an opportunistic infection should therefore be considered when encountering fingolimod-treated patients.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173513PMC
http://dx.doi.org/10.2169/internalmedicine.55.7255DOI Listing

Publication Analysis

Top Keywords

disseminated cryptococcosis
8
multiple sclerosis
8
sclerosis treated
8
treated fingolimod
8
cd4 lymphocytopenia
8
cryptococcosis 63-year-old
4
63-year-old patient
4
patient multiple
4
fingolimod report
4
report case
4

Similar Publications

Cryptococcosis is a fungal disease in humans and animals, caused by the and species complexes. Clinical cryptococcosis primarily manifests as upper respiratory tract disease; however, dissemination to other organs, particularly the brain, can occur. Nasal colonisation and subclinical cryptococcosis are common in koalas () due to their shared environmental niche with : trees.

View Article and Find Full Text PDF

About two French cases of disseminated Cryptococcus neoformans infection associated with COVID-19.

FEMS Microbiol Lett

January 2025

Service de Parasitologie-Mycologie, CHU Clermont-Ferrand, 3IHP, Clermont-Ferrand, France.

Background: SARS-CoV-2 infection is an acute respiratory distress syndrome associated with immune dysfunction, causing COVID-19 disease. The use of immunosuppressive drugs in its treatment increases the risk of opportunistic infections. In particular, opportunistic fungal infections have been described in initially non-immunocompromised patients with severe COVID-19 disease.

View Article and Find Full Text PDF

is a fungal pathogen that can cause lethal disease in immunocompromised patients. Immunocompetent host immune responses, such as formation of pulmonary granulomas, control the infection and prevent disseminated disease. Little is known about the immunological conditions establishing the latent infection granuloma in the lungs.

View Article and Find Full Text PDF

Diagnosis of disseminated cryptococcosis via iliac bone marrow aspirate analysis.

IDCases

December 2024

Clinical Laboratory, Department of Clinical Laboratory, Shenzhen Longhua District People's Hospital, Shenzhen, PR China.

HIV infection frequently affects multiple systems, with hematological manifestations being the most prevalent. In some cases, cryptococcosis serves as the initial manifestation and a cause of infection involving HIV-positive patients. This case report describes a patient with thrombocytopenia who incidentally discovered infiltrating the bone marrow upon bone marrow smear examination, highlighting that examining bone marrow is essential in diagnosing pancytopenia resulting from opportunistic fungal infections like cryptococcosis, especially in individuals with compromised immune systems.

View Article and Find Full Text PDF

Invasive fungal diseases are an important public health concern due to an increase in the at-risk population and high mortality associated with these infections. Managing invasive fungal infections poses a significant challenge given the limited antifungal options and the emergence of resistance in key fungal pathogens. Through a comprehensive approach, we evaluated the in vitro antifungal activity and the in vivo efficacy of two novel lipopeptides, AF and AF in murine models of disseminated candidiasis, cryptococcosis, and aspergillosis.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!