In positron tomographs using a small number of position-sensitive detectors, each detector must operate at high singles event rates, especially during dynamic studies. To enable the PENN-PET tomography to perform studies involving high data rates, the high count rate behaviour of the position-sensitive scintillation detector used in the tomograph was investigated at singles rates in excess of 2 million counts per second (MCPS). Detector dead-time, minimised through the use of pulse clipping (clipping time, 120 ns), is a maximum of 20% at the highest data rates. At 2 MCPS and 240 ns pulse integration time, the full width at half maximum of the point spread function (PSF) worsens by approximately 20% over its low count rate value of 5.2 mm. Furthermore, at high count rates, pulse pile-up produces long tails in the PSF along the detector's long axis. These tails were reduced or eliminated through the use of a shortened pulse integration time (160 ns instead of 240 ns), an upper level energy discriminator and a local centroid event positioning algorithm. Detector performance was characterised for different combinations of these event processing techniques, and the mechanisms by which pulse pile-up distorts the high count rate PSF were investigated using computer simulations. With the incorporation of the high count rate event processing techniques, the detector's count rate capability enables the PENN-PET tomograph to handle most current imaging protocols.
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http://dx.doi.org/10.1088/0031-9155/34/4/003 | DOI Listing |
PLoS One
January 2025
Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Background: To study the efficacy and safety of Polyethylene glycolated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) in the prevention of neutropenia during concurrent chemoradiotherapy for nasopharyngeal carcinoma (NPC).
Methods: This is a single-center, prospective, randomized controlled study conducted from June 1, 2021, to October 31, 2022 on patients diagnosed with locally advanced NPC. Participants were divided into an experimental group and a control group.
PLoS One
January 2025
Department of Biological Sciences, Purdue University Fort Wayne, Fort Wayne, Indiana, United States of America.
Present study aimed at improving the immune and antioxidant response of Pacific white shrimp (Litopenaeus vannamei) cultured at high stocking density fed with 0.2% supplementation of lauric acid (LA) and N-acetyl-L-cysteine (NAC). Shrimp (initial average weight = 0.
View Article and Find Full Text PDFEur J Pediatr
January 2025
Department of Biostatistics and Medical Informatics, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.
Unlabelled: This study aims to evaluate the clinical course of critical pertussis illness to the pediatric intensive care unit in Istanbul. The study was conducted as a multicenter, retrospective study between January 1, 2023, and December 31, 2023. Cases with positive polymerase chain reaction testing for Bordetella pertussis of nasopharyngeal swab samples within the first 24 h of pediatric intensive care unit admission were recorded.
View Article and Find Full Text PDFIntegr Cancer Ther
January 2025
Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.
Objective: To observe the clinical efficacy of Dendrobium officinale in the treatment of radiotherapy-induced oral mucositis in nasopharyngeal carcinoma patients, and to explore its regulating effect on immune function and oral microbiota by comparing immune-related factors and oral microbiota before and after the intervention.
Methods: We conducted a randomized double-blinded controlled trial in Zhejiang Cancer Hospital. Sixty patients with nasopharyngeal cancer combined with radiotherapy-induced oral mucositis were randomly divided into a study group and control group, with 30 cases in each group The study group used compound vitamin B12 solution and Dendrobium tea drink, and the control group simply used compound vitamin B12 solution rinse.
Heliyon
January 2025
Department of Otolaryngology Head and Neck Surgery, the Second People's Hospital of Shenzhen, the First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong Province, 518035, China.
Background: Despite advancements in medical science, the 5-year survival rate for laryngeal squamous cell carcinoma remains low, posing significant challenges in clinical management. This study explores the evolution of key topics and trends in laryngeal cancer research. Bibliometric and knowledge graph analysis are utilized to assess contributions in treating this carcinoma and to forecast emerging research hotspots that may enhance future clinical outcomes.
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