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Resource availability for CNS tumor diagnostics in the Asian Oceanian region: A survey by the Asian Oceanian Society of Neuropathology committee for Adapting Diagnostic Approaches for Practical Taxonomy in Resource-Restrained Regions (AOSNP-ADAPTR).
Brain Pathol
January 2025
Department of Laboratory Medicine and Pathology, Tokyo Metropolitan Neurological Hospital, Tokyo Metropolitan Hospital Organization, Tokyo, Japan.
The shift toward a histo-molecular approach in World Health Organization classification of central nervous system tumors (WHO CNS5) emphasizes the critical role of molecular testing, such as next-generation sequencing (NGS) and DNA methylation profiling, for accurate diagnosis. However, implementing these advanced techniques is particularly challenging in resource-constrained countries. To address this, the Asian Oceanian Society of Neuropathology committee for Adapting Diagnostic Approaches for Practical Taxonomy in Resource-Restrained Regions (AOSNP-ADAPTR) was initiated to help pathologists in resource-limited regions to implement WHO CNS5 diagnoses using simpler diagnostic tools, mainly immunohistochemistry.
View Article and Find Full Text PDFInsight into the structure, oligomerization, and the role in drug resistance of human UDP-glucuronosyltransferases.
Arch Toxicol
January 2025
Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Human UDP-glucuronosyltransferases (UGTs) are pivotal phase II metabolic enzymes facilitating the transfer of glucuronic acid from UDP-glucuronic acid (UDPGA) to various substrates. UGTs are classic type I transmembrane glycoproteins, mainly localized in the endoplasmic reticulum (ER) membrane. This review comprehensively explores UGTs, encompassing gene expression, functional characteristics, substrate specificity, and metabolic mechanisms.
View Article and Find Full Text PDFInfluence of snow cover on albedo reduction by snow algae.
mBio
January 2025
Department of Plant and Microbial Biology, University of Minnesota, St. Paul, Minnesota, USA.
Unlabelled: Snow algae darken the surface of snow, reducing albedo and accelerating melt. However, the impact of subsurface snow algae (e.g.
View Article and Find Full Text PDFThe Role of Neuropsychology in the Management of Spinal Cord Injury: A Comprehensive Literature Review.
World Neurosurg
January 2025
Department of Neurosurgery, Hurley Medical Center, MI, USA.
Spinal cord injury (SCI) poses a complex set of physiological, psychological, and cognitive challenges that significantly affect an individual's quality of life. Analysis of longitudinal studies reveals that cognitive changes following SCI are often underestimated yet significantly impact patient's ability to adapt to their new circumstances. However, the role of neuropsychology in SCI management and rehabilitation is yet to be elucidated.
View Article and Find Full Text PDFHiking Trails Facilitate the Spread of a Native High-Arctic Species.
Ecol Evol
January 2025
Dynamic Macroecology/Land Change Science Swiss Federal Institute for Forest, Snow and Landscape Research WSL Birmensdorf Switzerland.
High-Arctic environments are facing an elevated pace of warming and increasing human activities, making them more susceptible to the introduction and spread of alien species. We investigated the role of human disturbance in facilitating the spread of a native plant () in a high-Arctic natural environment close to Isfjord Radio station and along adjacent hiking trails at Kapp Linné, Svalbard. We reconstructed the spatial pattern of the arrival and spread of at Kapp Linné by combining historical records of the species occurrence (1928-2018) with a contemporary survey of the plant abundance along the main hiking trail (2023 survey) and tested the relative effects of altitude and proximity to hiking trails on the species density via a generalised linear model (GLM).
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